Abstract
DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (Le X). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection
Original language | English |
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Pages (from-to) | 5778 - 5786 |
Number of pages | 9 |
Journal | Organic and Biomolecular Chemistry |
Volume | 9 |
Issue number | 16 |
DOIs | |
Publication status | Published - 2011 |
Externally published | Yes |