Second generation of fucose-based DC-SIGN ligands: Affinity improvement and specificity versus Langerin

Manuel Andreini, Daniela Doknic, Ieva Sutkeviciute, Jose J Reina, Janxin Duan, Eric Chabrol, Michel Thepaut, Elisabetta Moroni, Fabio Doro, Laura Belvisi, Joerg Weiser, Javier Rojo, Franck Fieschi, Anna Bernardi

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Abstract

DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (Le X). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection
Original languageEnglish
Pages (from-to)5778 - 5786
Number of pages9
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number16
DOIs
Publication statusPublished - 2011
Externally publishedYes

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