Sea anemone peptides

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Sea anemone venoms continue to afford a range of interesting new peptides directed against a range of biological targets. The first complete genome of a sea anemone was described recently, and its complement of toxins has been subject to various analyses. Concurrently, expressed sequence tag analyses of other anemones have identified many putative peptide toxins, while transcriptomic analyses may be expected to identify even more in the near future. Venom proteomic analyses are also revealing novel peptide toxins. Of those peptides that have been isolated, synthesized, or expressed, and then characterized functionally, the majority interact with sodium or potassium channels, although peptides binding to other targets are beginning to emerge, including one that modulates TRPV1 activity. Some of these peptides, in particular those capable of selectively blocking certain potassium channels, are being developed as new therapeutic leads.
Original languageEnglish
Title of host publicationHandbook of Biologically Active Peptides
EditorsAbba J Kastin
Place of PublicationSan Diego CA USA
PublisherElsevier
Pages430 - 436
Number of pages7
EditionSecond Edition
ISBN (Print)9780123850959
DOIs
Publication statusPublished - 2013

Cite this

Norton, R. S. (2013). Sea anemone peptides. In A. J. Kastin (Ed.), Handbook of Biologically Active Peptides (Second Edition ed., pp. 430 - 436). San Diego CA USA: Elsevier. https://doi.org/10.1016/B978-0-12-385095-9.00060-9
Norton, Raymond Stanley. / Sea anemone peptides. Handbook of Biologically Active Peptides. editor / Abba J Kastin. Second Edition. ed. San Diego CA USA : Elsevier, 2013. pp. 430 - 436
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Norton, RS 2013, Sea anemone peptides. in AJ Kastin (ed.), Handbook of Biologically Active Peptides. Second Edition edn, Elsevier, San Diego CA USA, pp. 430 - 436. https://doi.org/10.1016/B978-0-12-385095-9.00060-9

Sea anemone peptides. / Norton, Raymond Stanley.

Handbook of Biologically Active Peptides. ed. / Abba J Kastin. Second Edition. ed. San Diego CA USA : Elsevier, 2013. p. 430 - 436.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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Norton RS. Sea anemone peptides. In Kastin AJ, editor, Handbook of Biologically Active Peptides. Second Edition ed. San Diego CA USA: Elsevier. 2013. p. 430 - 436 https://doi.org/10.1016/B978-0-12-385095-9.00060-9