Screening investigations in small-for-gestational-age near-term and term infants

Mohan B. Krishnamurthy, Abigail Popiel, Atul Malhotra

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

The aims of this study are to examine how frequently near-term and term small-for-gestational-age (SGA) infants were investigated in our clinical practice, whether being born less than the third centile for weight increased the yield of positive investigations, and whether there were additional characteristics in infants with positive investigations. This retrospective cohort study was compiled using a database of a large maternity network, using the search near term and term gestational age (greater than or equal to 35 weeks) over a span of 4 years. SGA babies were further filtered into less than the tenth centile and third centile. Out of a population of 30,461 infants in the study period, 3437 (11.3%) SGA infants were identified. Four hundred fifteen SGA infants (12.1%) underwent screening investigations, of which 49 infants (11.8%) yielded a positive investigation. 27.2% of karyotypes, 12.8% of cranial ultrasounds and 0.4% of urine CMV tests showed positive results in < 10th centile group. Being born less than the third centile for weight did not increase the yield of positive investigations. Most infants with positive investigations had an additional maternal or neonatal characteristic or risk factor present. Conclusion: SGA babies without additional maternal or neonatal characteristics have a poor yield on neonatal screening investigations. Additional characteristics may be considered while deciding whether a SGA infant needs screening investigation.What is Known:• Small-for-gestational-age (SGA) infants have an increased risk of short- and long-term complications.• Whilst the causes for SGA are multifactorial, there has been a tendency to undertake screening investigations like Toxoplasma, Others, Rubella, Cytomegalovirus, Herpes group of viruses (TORCH) screening and cranial ultrasounds in the neonatal period.What is New:• Comprehensive study investigating the rates of screening in near-term and term SGA population.• The yield of screening tests for near-term and term SGA infants without additional antenatal and postnatal characteristics is low.

Original languageEnglish
Pages (from-to)1707-1712
Number of pages6
JournalEuropean Journal of Pediatrics
Volume176
Issue number12
DOIs
Publication statusPublished - 1 Dec 2017

Keywords

  • Cranial ultrasound
  • Cytomegalovirus
  • IUGR
  • Karyotype

Cite this

Krishnamurthy, Mohan B. ; Popiel, Abigail ; Malhotra, Atul. / Screening investigations in small-for-gestational-age near-term and term infants. In: European Journal of Pediatrics. 2017 ; Vol. 176, No. 12. pp. 1707-1712.
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title = "Screening investigations in small-for-gestational-age near-term and term infants",
abstract = "The aims of this study are to examine how frequently near-term and term small-for-gestational-age (SGA) infants were investigated in our clinical practice, whether being born less than the third centile for weight increased the yield of positive investigations, and whether there were additional characteristics in infants with positive investigations. This retrospective cohort study was compiled using a database of a large maternity network, using the search near term and term gestational age (greater than or equal to 35 weeks) over a span of 4 years. SGA babies were further filtered into less than the tenth centile and third centile. Out of a population of 30,461 infants in the study period, 3437 (11.3{\%}) SGA infants were identified. Four hundred fifteen SGA infants (12.1{\%}) underwent screening investigations, of which 49 infants (11.8{\%}) yielded a positive investigation. 27.2{\%} of karyotypes, 12.8{\%} of cranial ultrasounds and 0.4{\%} of urine CMV tests showed positive results in < 10th centile group. Being born less than the third centile for weight did not increase the yield of positive investigations. Most infants with positive investigations had an additional maternal or neonatal characteristic or risk factor present. Conclusion: SGA babies without additional maternal or neonatal characteristics have a poor yield on neonatal screening investigations. Additional characteristics may be considered while deciding whether a SGA infant needs screening investigation.What is Known:• Small-for-gestational-age (SGA) infants have an increased risk of short- and long-term complications.• Whilst the causes for SGA are multifactorial, there has been a tendency to undertake screening investigations like Toxoplasma, Others, Rubella, Cytomegalovirus, Herpes group of viruses (TORCH) screening and cranial ultrasounds in the neonatal period.What is New:• Comprehensive study investigating the rates of screening in near-term and term SGA population.• The yield of screening tests for near-term and term SGA infants without additional antenatal and postnatal characteristics is low.",
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Screening investigations in small-for-gestational-age near-term and term infants. / Krishnamurthy, Mohan B.; Popiel, Abigail; Malhotra, Atul.

In: European Journal of Pediatrics, Vol. 176, No. 12, 01.12.2017, p. 1707-1712.

Research output: Contribution to journalArticleResearchpeer-review

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