Screening for preeclampsia in twin pregnancies

Carla Francisco, Mariana Gamito, Maya Reddy, Daniel L. Rolnik

Research output: Contribution to journalReview ArticleOtherpeer-review

10 Citations (Scopus)

Abstract

Twin pregnancies are an important risk factor for preeclampsia, a hypertensive disorder of pregnancy that is associated with a significant risk of maternal and perinatal morbidity. Given the burden of preeclampsia, the identification of women at high risk in early pregnancy is essential to allow for preventive strategies and close monitoring. In singleton pregnancies, the risk factors for preeclampsia are well established, and a combined first-trimester prediction model has been shown to adequately predict preterm disease. Furthermore, intervention with low-dose aspirin at 150 mg/day in those identified as high-risk reduces the rate of preterm preeclampsia by 62%. In contrast, risk factors for preeclampsia in twin pregnancies are less established, the proposed screening models have shown poor performance with high false-positive rates, and the benefit of aspirin for the prevention of preeclampsia is not clearly demonstrated. In this review, we examine the literature assessing prediction and prevention of preeclampsia in twin pregnancies.

Original languageEnglish
Pages (from-to)55-65
Number of pages11
JournalBest Practice and Research: Clinical Obstetrics and Gynaecology
Volume84
DOIs
Publication statusPublished - Nov 2022

Keywords

  • Aspirin
  • Multiple pregnancy
  • Prediction
  • Preeclampsia
  • Prevention
  • Twins

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