Screening-based translation of public research encounters painful problems

Research output: Contribution to journalLetterOther

Abstract

Whether identified through high throughput screening or in silico screening, and whether target-based or phenotypic, sets of hits will contain chemical con artists. Such pan-assay interference compounds (PAINS) and other subversive compounds continue to pollute the scientific literature. There are several angles of attack to aid identification of such nonprogressable molecules. One of these rules above all, and this is a demonstration of genuine structure-activity relationships. Recognition of this, which will require a greater effort in medicinal chemistry, will be of general benefit.
Original languageEnglish
Pages (from-to)229 - 234
Number of pages6
JournalA C S Medicinal Chemistry Letters
Volume6
Issue number3
DOIs
Publication statusPublished - 2015

Cite this

@article{67a5f99e336a4f2a8408a160a4f2b78f,
title = "Screening-based translation of public research encounters painful problems",
abstract = "Whether identified through high throughput screening or in silico screening, and whether target-based or phenotypic, sets of hits will contain chemical con artists. Such pan-assay interference compounds (PAINS) and other subversive compounds continue to pollute the scientific literature. There are several angles of attack to aid identification of such nonprogressable molecules. One of these rules above all, and this is a demonstration of genuine structure-activity relationships. Recognition of this, which will require a greater effort in medicinal chemistry, will be of general benefit.",
author = "Baell, {Jonathan Bayldon}",
year = "2015",
doi = "10.1021/acsmedchemlett.5b00032",
language = "English",
volume = "6",
pages = "229 -- 234",
journal = "A C S Medicinal Chemistry Letters",
issn = "1948-5875",
publisher = "ACS Publications",
number = "3",

}

Screening-based translation of public research encounters painful problems. / Baell, Jonathan Bayldon.

In: A C S Medicinal Chemistry Letters, Vol. 6, No. 3, 2015, p. 229 - 234.

Research output: Contribution to journalLetterOther

TY - JOUR

T1 - Screening-based translation of public research encounters painful problems

AU - Baell, Jonathan Bayldon

PY - 2015

Y1 - 2015

N2 - Whether identified through high throughput screening or in silico screening, and whether target-based or phenotypic, sets of hits will contain chemical con artists. Such pan-assay interference compounds (PAINS) and other subversive compounds continue to pollute the scientific literature. There are several angles of attack to aid identification of such nonprogressable molecules. One of these rules above all, and this is a demonstration of genuine structure-activity relationships. Recognition of this, which will require a greater effort in medicinal chemistry, will be of general benefit.

AB - Whether identified through high throughput screening or in silico screening, and whether target-based or phenotypic, sets of hits will contain chemical con artists. Such pan-assay interference compounds (PAINS) and other subversive compounds continue to pollute the scientific literature. There are several angles of attack to aid identification of such nonprogressable molecules. One of these rules above all, and this is a demonstration of genuine structure-activity relationships. Recognition of this, which will require a greater effort in medicinal chemistry, will be of general benefit.

UR - http://pubs.acs.org.ezproxy.lib.monash.edu.au/doi/pdf/10.1021/acsmedchemlett.5b00032

U2 - 10.1021/acsmedchemlett.5b00032

DO - 10.1021/acsmedchemlett.5b00032

M3 - Letter

VL - 6

SP - 229

EP - 234

JO - A C S Medicinal Chemistry Letters

JF - A C S Medicinal Chemistry Letters

SN - 1948-5875

IS - 3

ER -