TY - JOUR
T1 - Schizophrenia: a systematic review of the disease state, current therapeutics and their molecular mechanisms of action
AU - Shin, James
AU - Malone, Daniel
AU - Crosby, Ian
AU - Capuano, Benvenuto
PY - 2011
Y1 - 2011
N2 - The treatment of schizophrenia, one of the most debilitating mental illnesses, began by the serendipitous discovery of chlorpromazine. Since then, researchers have endeavored to find the cause of the illness but it remains unresolved. As a result, literature on the etiology of schizophrenia is littered with hypotheses and theories that are constantly reviewed, modified and rejected. Two hypotheses, however, have withstood the test of time and serve as the basis for the drug treatment, namely the dopamine and serotonin hypotheses. This review introduces the disease state, summarizes in detail the two leading hypotheses on schizophrenia, presents drugs that are currently available for treatment, and discusses some of the promising drug candidates based on their pre and early clinical trial results.
AB - The treatment of schizophrenia, one of the most debilitating mental illnesses, began by the serendipitous discovery of chlorpromazine. Since then, researchers have endeavored to find the cause of the illness but it remains unresolved. As a result, literature on the etiology of schizophrenia is littered with hypotheses and theories that are constantly reviewed, modified and rejected. Two hypotheses, however, have withstood the test of time and serve as the basis for the drug treatment, namely the dopamine and serotonin hypotheses. This review introduces the disease state, summarizes in detail the two leading hypotheses on schizophrenia, presents drugs that are currently available for treatment, and discusses some of the promising drug candidates based on their pre and early clinical trial results.
UR - http://www.ingentaconnect.com.ezproxy.lib.monash.edu.au/content/ben/cmc/2011/00000018/00000009/art00013?token=005d1dcee71063f4aba54405847447b492b2f7c7
M3 - Article
VL - 18
SP - 1380
EP - 1404
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
SN - 0929-8673
IS - 9
ER -