Scalable Synthesis of Sequence-Defined Oligomers via Photoflow Chemistry

Matthias Van De Walle, Kevin De Bruycker, Tanja Junkers, James P. Blinco, Christopher Barner-Kowollik

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)


The development of practical routes that enable the synthesis of unimolecular non-natural macromolecules on multi-gram scales remains a key challenge in polymer chemistry. Herein, we present a continuous flow setup employing the light-induced chemistry based on photocaged dienes as a controlled ligation system to establish a new platform for scalable monodisperse macromolecular synthesis. 800 mg of sequence-defined linear chains with 8 repeating units were obtained in a sequential protecting group based 2-step process. The current study demonstrates that photoflow synthesis is a viable approach to generate large quantities of monodisperse oligomers.

Original languageEnglish
Pages (from-to)225-228
Number of pages4
Issue number5
Publication statusPublished - 1 May 2019


  • continuous flow
  • flow chemistry
  • macromolecules
  • scalable synthesis
  • sequence-defined oligomers

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