Saturated vapor pressure of HFA152a-ethanol and HFO1234ze(E)-ethanol binary mixtures

Swetha Vutlapalli, Lingzhe Rao, Benjamin Myatt, Phil Cocks, Paul Young, Damon Honnery, Daniel J. Duke

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther


Hydrofluoroalkane propellants HFA134a and HFA227ea are being phased down under the Kigali amendment due to their high global warming potential. Propellants HFA152a and HFO1234ze(E) have been proposed as potential alternatives for pressurised metered dose inhalers (pMDIs). Knowledge of the fundamental thermodynamic properties of these alternative propellants is essential to predict and optimise device performance. The vapor pressure of low-GWP propellant binary mixtures with ethanol for use in solution formulations are presently not available in the literature. In this paper, the saturated vapor pressures of HFA152a and HFO1234ze(E) have been measured using a constant-volume technique. For temperatures below 45°C the relative deviations of vapor pressures of HFA152a and HFO1234ze(E) are below 5% and 3.5% as compared with REFPROP10.0, respectively. We show the vapor pressure dependency on ethanol cosolvent concentration for HFA152a and HFO1234ze(E) at a concentration of 8% w/w.
Original languageEnglish
Title of host publicationProceedings of Drug Delivery to the Lungs Conference 2022
Number of pages4
Publication statusPublished - 2022
EventDrug Delivery to the Lungs Conference 2022 - Edinburgh International Conference Centre, Edinburgh, United Kingdom
Duration: 7 Dec 20229 Dec 2022


ConferenceDrug Delivery to the Lungs Conference 2022
Abbreviated titleDDL 2022
Country/TerritoryUnited Kingdom
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