Saturated vapor pressure of HFA152a-ethanol and HFO1234ze(E)-ethanol binary mixtures

Swetha Vutlapalli; Lingzhe Rao; Benjamin  Myatt; Phil Cocks; Paul Young; Damon Honnery; Daniel J. Duke

Saturated vapor pressure of HFA152a-ethanol and HFO1234ze(E)-ethanol binary mixtures

Swetha Vutlapalli, Lingzhe Rao, Benjamin Myatt, Phil Cocks, Paul Young, Damon Honnery, Daniel J. Duke

Mechanical & Aerospace Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

Abstract

Hydrofluoroalkane propellants HFA134a and HFA227ea are being phased down under the Kigali amendment due to their high global warming potential. Propellants HFA152a and HFO1234ze(E) have been proposed as potential alternatives for pressurised metered dose inhalers (pMDIs). Knowledge of the fundamental thermodynamic properties of these alternative propellants is essential to predict and optimise device performance. The vapor pressure of low-GWP propellant binary mixtures with ethanol for use in solution formulations are presently not available in the literature. In this paper, the saturated vapor pressures of HFA152a and HFO1234ze(E) have been measured using a constant-volume technique. For temperatures below 45°C the relative deviations of vapor pressures of HFA152a and HFO1234ze(E) are below 5% and 3.5% as compared with REFPROP10.0, respectively. We show the vapor pressure dependency on ethanol cosolvent concentration for HFA152a and HFO1234ze(E) at a concentration of 8% w/w.

Original language	English
Title of host publication	Proceedings of Drug Delivery to the Lungs Conference 2022
Pages	171-174
Number of pages	4
Volume	33
Publication status	Published - 2022
Event	Drug Delivery to the Lungs Conference 2022 - Edinburgh International Conference Centre, Edinburgh, United Kingdom Duration: 7 Dec 2022 → 9 Dec 2022 https://ddl-conference.com/ddl2022-programme/

Conference

Conference	Drug Delivery to the Lungs Conference 2022
Abbreviated title	DDL 2022
Country/Territory	United Kingdom
City	Edinburgh
Period	7/12/22 → 9/12/22
Internet address	https://ddl-conference.com/ddl2022-programme/

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@inproceedings{77ef62334744449681538f645e87fcfb,

title = "Saturated vapor pressure of HFA152a-ethanol and HFO1234ze(E)-ethanol binary mixtures",

abstract = "Hydrofluoroalkane propellants HFA134a and HFA227ea are being phased down under the Kigali amendment due to their high global warming potential. Propellants HFA152a and HFO1234ze(E) have been proposed as potential alternatives for pressurised metered dose inhalers (pMDIs). Knowledge of the fundamental thermodynamic properties of these alternative propellants is essential to predict and optimise device performance. The vapor pressure of low-GWP propellant binary mixtures with ethanol for use in solution formulations are presently not available in the literature. In this paper, the saturated vapor pressures of HFA152a and HFO1234ze(E) have been measured using a constant-volume technique. For temperatures below 45°C the relative deviations of vapor pressures of HFA152a and HFO1234ze(E) are below 5% and 3.5% as compared with REFPROP10.0, respectively. We show the vapor pressure dependency on ethanol cosolvent concentration for HFA152a and HFO1234ze(E) at a concentration of 8% w/w.",

author = "Swetha Vutlapalli and Lingzhe Rao and Benjamin Myatt and Phil Cocks and Paul Young and Damon Honnery and Duke, {Daniel J.}",

year = "2022",

language = "English",

volume = "33",

pages = "171--174",

booktitle = "Proceedings of Drug Delivery to the Lungs Conference 2022",

note = "Drug Delivery to the Lungs Conference 2022, DDL 2022 ; Conference date: 07-12-2022 Through 09-12-2022",

url = "https://ddl-conference.com/ddl2022-programme/",

}

TY - GEN

T1 - Saturated vapor pressure of HFA152a-ethanol and HFO1234ze(E)-ethanol binary mixtures

AU - Vutlapalli, Swetha

AU - Rao, Lingzhe

AU - Myatt, Benjamin

AU - Cocks, Phil

AU - Young, Paul

AU - Honnery, Damon

AU - Duke, Daniel J.

PY - 2022

Y1 - 2022

N2 - Hydrofluoroalkane propellants HFA134a and HFA227ea are being phased down under the Kigali amendment due to their high global warming potential. Propellants HFA152a and HFO1234ze(E) have been proposed as potential alternatives for pressurised metered dose inhalers (pMDIs). Knowledge of the fundamental thermodynamic properties of these alternative propellants is essential to predict and optimise device performance. The vapor pressure of low-GWP propellant binary mixtures with ethanol for use in solution formulations are presently not available in the literature. In this paper, the saturated vapor pressures of HFA152a and HFO1234ze(E) have been measured using a constant-volume technique. For temperatures below 45°C the relative deviations of vapor pressures of HFA152a and HFO1234ze(E) are below 5% and 3.5% as compared with REFPROP10.0, respectively. We show the vapor pressure dependency on ethanol cosolvent concentration for HFA152a and HFO1234ze(E) at a concentration of 8% w/w.

AB - Hydrofluoroalkane propellants HFA134a and HFA227ea are being phased down under the Kigali amendment due to their high global warming potential. Propellants HFA152a and HFO1234ze(E) have been proposed as potential alternatives for pressurised metered dose inhalers (pMDIs). Knowledge of the fundamental thermodynamic properties of these alternative propellants is essential to predict and optimise device performance. The vapor pressure of low-GWP propellant binary mixtures with ethanol for use in solution formulations are presently not available in the literature. In this paper, the saturated vapor pressures of HFA152a and HFO1234ze(E) have been measured using a constant-volume technique. For temperatures below 45°C the relative deviations of vapor pressures of HFA152a and HFO1234ze(E) are below 5% and 3.5% as compared with REFPROP10.0, respectively. We show the vapor pressure dependency on ethanol cosolvent concentration for HFA152a and HFO1234ze(E) at a concentration of 8% w/w.

UR - https://ddl-conference.com/ddl2022/conference-papers/saturated-vapor-pressure-of-hfa152a-ethanol-and-hfo1234zee-ethanol-binary-mixtures/

M3 - Conference Paper

VL - 33

SP - 171

EP - 174

BT - Proceedings of Drug Delivery to the Lungs Conference 2022

T2 - Drug Delivery to the Lungs Conference 2022

Y2 - 7 December 2022 through 9 December 2022

ER -

Saturated vapor pressure of HFA152a-ethanol and HFO1234ze(E)-ethanol binary mixtures

Abstract

Conference

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