Mice harboring mutations in the IL-4 gene (IL-4-/-) were infected with a range of Salmonella typhimurium HWSH derivatives using different routes of infection. Compared with IL-4+/+ mice, IL-4-/- mice exhibited a delayed time to death following infection with wild-type S. typhimurium HWSH. Croups of IL-4+/+ mice infected with S. typhimurium HWSH purE, a less virulent derivative, showed sporadic deaths and harbored micro- or macroabscesses in their tissues, particularly associated with the liver. However, IL-4-/- mice infected with similar doses of S. typhimurium HWSH purE bacteria were resistant to killing and failed to develop detectable abscesses. Abscess formation in IL-4-/- mice could be induced by i.v. administration of rlL-4 during the S. typhimurium HWSH purE infection. The immune response in both IL-4-/- and IL-4+/+ mice was of the Th1-type. Viable salmonella bacteria could be found associated with abscesses. Both IL-4-/- and IL-4+/+ mice were resistant to killing by S. typhimurium aroA.
|Number of pages||8|
|Journal||Journal of Immunology|
|Publication status||Published - 15 Aug 1997|