TY - JOUR
T1 - Salmonella typhimurium Infections in Mice Deficient in Interleukin-4 Production
T2 - Role of IL-4 in Infection-Associated Pathology
AU - Everest, Paul
AU - Allen, Jenny
AU - Papakonstantinopoulou, Anastasia
AU - Mastroeni, Pietro
AU - Roberts, Mark
AU - Dougan, Gordon
PY - 1997/8/15
Y1 - 1997/8/15
N2 - Mice harboring mutations in the IL-4 gene (IL-4-/-) were infected with a range of Salmonella typhimurium HWSH derivatives using different routes of infection. Compared with IL-4+/+ mice, IL-4-/- mice exhibited a delayed time to death following infection with wild-type S. typhimurium HWSH. Croups of IL-4+/+ mice infected with S. typhimurium HWSH purE, a less virulent derivative, showed sporadic deaths and harbored micro- or macroabscesses in their tissues, particularly associated with the liver. However, IL-4-/- mice infected with similar doses of S. typhimurium HWSH purE bacteria were resistant to killing and failed to develop detectable abscesses. Abscess formation in IL-4-/- mice could be induced by i.v. administration of rlL-4 during the S. typhimurium HWSH purE infection. The immune response in both IL-4-/- and IL-4+/+ mice was of the Th1-type. Viable salmonella bacteria could be found associated with abscesses. Both IL-4-/- and IL-4+/+ mice were resistant to killing by S. typhimurium aroA.
AB - Mice harboring mutations in the IL-4 gene (IL-4-/-) were infected with a range of Salmonella typhimurium HWSH derivatives using different routes of infection. Compared with IL-4+/+ mice, IL-4-/- mice exhibited a delayed time to death following infection with wild-type S. typhimurium HWSH. Croups of IL-4+/+ mice infected with S. typhimurium HWSH purE, a less virulent derivative, showed sporadic deaths and harbored micro- or macroabscesses in their tissues, particularly associated with the liver. However, IL-4-/- mice infected with similar doses of S. typhimurium HWSH purE bacteria were resistant to killing and failed to develop detectable abscesses. Abscess formation in IL-4-/- mice could be induced by i.v. administration of rlL-4 during the S. typhimurium HWSH purE infection. The immune response in both IL-4-/- and IL-4+/+ mice was of the Th1-type. Viable salmonella bacteria could be found associated with abscesses. Both IL-4-/- and IL-4+/+ mice were resistant to killing by S. typhimurium aroA.
UR - http://www.scopus.com/inward/record.url?scp=0031571208&partnerID=8YFLogxK
M3 - Article
C2 - 9257845
AN - SCOPUS:0031571208
VL - 159
SP - 1820
EP - 1827
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 4
ER -