Abstract
We concur with Jacob and
Chappell that the interpretation of our results requires
careful consideration, primarily because our
study was conducted as a subgroup analysis of the
SAFE study.1 However, given the equivalence of
injury severity at baseline in the saline group and
the albumin group, the similar resuscitation end
points achieved under double-blind conditions,
and the significant difference in long-term mortality
between the two study groups, a reevaluation
of purported crystalloid-specific and colloid-specific
effects is warranted. Considering the additional
cost of albumin, we recommend that saline be
used preferentially in patients with traumatic brain
injury until fluid strategies with other crystalloids
or synthetic colloids have been evaluated under the
same rigorous conditions applied in our study.
Original language | English |
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Pages (from-to) | 2635 - 2636 |
Number of pages | 2 |
Journal | The New England Journal of Medicine |
Volume | 357 |
Issue number | 25 |
Publication status | Published - 2007 |