Safety of withholding anticoagulation in pregnant women with suspected deep vein thrombosis following negative serial compression ultrasound and iliac vein imaging

Weeshian Chan, Frederick Spencer, Agnes Lee, Sanjeev Chunilal, James Douketis, Marc Rodger, Jeffrey S Ginsberg

    Research output: Contribution to journalArticleResearchpeer-review

    36 Citations (Scopus)

    Abstract

    Compression ultrasonography performed serially over a 7-day period is recommended for the diagnosis of deep vein thrombosis in symptomatic pregnant women, but whether this approach is safe is unknown. We evaluated the safety of withholding anticoagulation from pregnant women with suspected deep vein thrombosis following negative serial compression ultrasonography and iliac vein imaging. Methods: Consecutive pregnant women who presented with suspected deep vein thrombosis underwent compression ultrasonography and Doppler imaging of the iliac vein of the symptomatic leg(s). Women whose initial test results were negative underwent serial testing on 2 occasions over the next 7 days. Women not diagnosed with deep vein thrombosis were followed for a minimum of 3 months for the development of symptomatic deep vein thrombosis or pulmonary embolism. Results: In total, 221 pregnant women presented with suspected deep vein thrombosis. Deep vein thrombosis was diagnosed in 16 (7.2 ) women by initial compression ultrasonography and Doppler studies; none were identified as having deep vein thrombosis on serial testing. One patient with normal serial testing had a pulmonary embolism diagnosed 7 weeks later. The overall prevalence of deep vein thrombosis was 7.7 (17/221); of these, 65 (11/17) of cases were isolated to the ilio - femoral veins and 12 (2/17) were isolated iliac deep vein thromboses. The incidence of venous thromboembolism during follow-up was 0.49 (95 confidence interval [CI] 0.09 -2.71 ). The sensitivity of serial compression ultrasonography with Doppler imaging was 94.1 (95 CI 69.2 -99.7 ), the negative predictive value was 99.5 (95 CI 96.9 -100 ), and the negative likelihood ratio was 0.068 (95 CI 0.01-0.39). Interpretation: Serial compression ultrasonography with Doppler imaging of the iliac vein performed over a 7-day period excludes deep-vein thrombosis in symptomatic pregnant women. ? 2013 Canadian Medical Association or its licensors.
    Original languageEnglish
    Pages (from-to)E194 - E200
    Number of pages7
    JournalCanadian Medical Association Journal
    Volume185
    Issue number4
    DOIs
    Publication statusPublished - 2013

    Cite this