Seguridad de los antipsicóticos atípicos en el embarazo

Translated title of the contribution: Safety of atypical antipsychotics during pregnancy

Alexia Camuñas Palacín, Jasmin Grigg, Heather Alison Gilbert, Rosie Worsley, Emmy Gavrilidis, Jayashri Kulkarni

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Introduction: Since the introduction of second generation antipsychotics (SGAs), prescribing has increased considerably in women with a range of mental illnesses, and now increasingly used by women during pregnancy. However, information regarding the safety of SGAs during pregnancy is limited.

Objectives: To clarify the impact of SGAs during pregnancy from the available literature, and to provide a clinical support tool.

Methodology: An exhaustive review of the available literature was conducted. Following the PRISMA criteria, literature published from May 1995 to October 2015 was identified from PubMed (Medline), SCOPUS, LILACS and MEDES databases.

Results: The search yielded a total of 192 studies after duplicates were excluded, and 47 articles were included in the review in accordance with the inclusion criteria.

Conclusions: While more research is needed, SGAs do not appear to cause marked congenital foetal harm. According to the available literature, in utero exposure to SGAs is associated with some neonatal and obstetric complications. While olanzapine, and clozapine in particular, is associated with increased risk of gestational diabetes and large for gestational age newborns, from this review of the literature it is clear that treating mental illness during pregnancy is vital and promotes better outcomes for both mother and infant. Currently olanzapine and quetiapine are the most frequently used SGAs during pregnancy, and despite some risks observed, overall safety is reported.
Translated title of the contributionSafety of atypical antipsychotics during pregnancy
Original languageSpanish
Pages (from-to)23 - 28
Number of pages6
JournalPsiquiatria Biologica
Volume23
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Atypical antipsychotics
  • New antipsychotics
  • Pregnancy
  • Pregnant Pregnant woman
  • Second generation antipsychotics

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