Safety evaluation and antihyperlipidemia effect of aqueous extracts from fermented puerh tea

Ping Xu; Le Ying; Jing Wu; Dedong Kong; Yuefei Wang

doi:10.1039/c5fo01389e

Safety evaluation and antihyperlipidemia effect of aqueous extracts from fermented puerh tea

Ping Xu, Le Ying, Jing Wu, Dedong Kong, Yuefei Wang

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

Fermented puerh tea, having undergone a long period of secondary oxidization and fermentation, has become more and more popular in recent years. In the present paper, a safety evaluation of aqueous extracts from fermented puerh tea (EFPT) was performed, including an oral acute toxicity study in rats and mice, mutation tests, a mouse micronucleus test, mouse sperm abnormality test and a 30 day feeding study in rats. Meanwhile, the antihyperlipidemia effect of EFPT was investigated as well. It was found that the oral maximum tolerated dose of EFPT was more than 10.0 g per kg body weight both in rats and mice. And it had no mutagenicity as judged by negative experimental results of the mutation test. No abnormal symptoms, clinical signs or deaths have been found in rats in each group throughout the experiments. In addition, EFPT in this study showed certain effects on hyperlipidemia.

Original language	English
Pages (from-to)	2667-2674
Number of pages	8
Journal	Food & Function
Volume	7
Issue number	6
DOIs	https://doi.org/10.1039/c5fo01389e
Publication status	Published - Jun 2016
Externally published	Yes

Access to Document

10.1039/c5fo01389e

Cite this

@article{ef633c5228034a46944fad90ab7e41a0,

title = "Safety evaluation and antihyperlipidemia effect of aqueous extracts from fermented puerh tea",

abstract = "Fermented puerh tea, having undergone a long period of secondary oxidization and fermentation, has become more and more popular in recent years. In the present paper, a safety evaluation of aqueous extracts from fermented puerh tea (EFPT) was performed, including an oral acute toxicity study in rats and mice, mutation tests, a mouse micronucleus test, mouse sperm abnormality test and a 30 day feeding study in rats. Meanwhile, the antihyperlipidemia effect of EFPT was investigated as well. It was found that the oral maximum tolerated dose of EFPT was more than 10.0 g per kg body weight both in rats and mice. And it had no mutagenicity as judged by negative experimental results of the mutation test. No abnormal symptoms, clinical signs or deaths have been found in rats in each group throughout the experiments. In addition, EFPT in this study showed certain effects on hyperlipidemia.",

author = "Ping Xu and Le Ying and Jing Wu and Dedong Kong and Yuefei Wang",

note = "Publisher Copyright: {\textcopyright} 2016 The Royal Society of Chemistry.",

year = "2016",

month = jun,

doi = "10.1039/c5fo01389e",

language = "English",

volume = "7",

pages = "2667--2674",

journal = "Food & Function",

issn = "2042-6496",

publisher = "The Royal Society of Chemistry",

number = "6",

}

TY - JOUR

T1 - Safety evaluation and antihyperlipidemia effect of aqueous extracts from fermented puerh tea

AU - Xu, Ping

AU - Ying, Le

AU - Wu, Jing

AU - Kong, Dedong

AU - Wang, Yuefei

PY - 2016/6

Y1 - 2016/6

N2 - Fermented puerh tea, having undergone a long period of secondary oxidization and fermentation, has become more and more popular in recent years. In the present paper, a safety evaluation of aqueous extracts from fermented puerh tea (EFPT) was performed, including an oral acute toxicity study in rats and mice, mutation tests, a mouse micronucleus test, mouse sperm abnormality test and a 30 day feeding study in rats. Meanwhile, the antihyperlipidemia effect of EFPT was investigated as well. It was found that the oral maximum tolerated dose of EFPT was more than 10.0 g per kg body weight both in rats and mice. And it had no mutagenicity as judged by negative experimental results of the mutation test. No abnormal symptoms, clinical signs or deaths have been found in rats in each group throughout the experiments. In addition, EFPT in this study showed certain effects on hyperlipidemia.

AB - Fermented puerh tea, having undergone a long period of secondary oxidization and fermentation, has become more and more popular in recent years. In the present paper, a safety evaluation of aqueous extracts from fermented puerh tea (EFPT) was performed, including an oral acute toxicity study in rats and mice, mutation tests, a mouse micronucleus test, mouse sperm abnormality test and a 30 day feeding study in rats. Meanwhile, the antihyperlipidemia effect of EFPT was investigated as well. It was found that the oral maximum tolerated dose of EFPT was more than 10.0 g per kg body weight both in rats and mice. And it had no mutagenicity as judged by negative experimental results of the mutation test. No abnormal symptoms, clinical signs or deaths have been found in rats in each group throughout the experiments. In addition, EFPT in this study showed certain effects on hyperlipidemia.

UR - http://www.scopus.com/inward/record.url?scp=84975520658&partnerID=8YFLogxK

U2 - 10.1039/c5fo01389e

DO - 10.1039/c5fo01389e

M3 - Article

C2 - 27181163

AN - SCOPUS:84975520658

SN - 2042-6496

VL - 7

SP - 2667

EP - 2674

JO - Food & Function

JF - Food & Function

IS - 6

ER -

Safety evaluation and antihyperlipidemia effect of aqueous extracts from fermented puerh tea

Abstract

Access to Document

Other files and links

Cite this