Projects per year
Abstract
Growing evidence suggests Attention Deficit Hyperactivity Disorder (ADHD) often co-occurs with Autism Spectrum Disorder (ASD), and a better understanding of the nature of their overlap, including at a neurobiological level, is needed. Research has implicated cerebellar-networks as part of the neural-circuitry disrupted in ASD, but little research has been carried out to investigate this in ADHD. We investigated cerebellar integrity using a double-step saccade adaptation paradigm in a group of male children age 8–15 (n = 12) diagnosed with ADHD-Combined Type (-CT). Their performance was compared to a group of age and IQ-matched typically developing (TD) controls (n = 12). Parent reported symptoms of ADHD-CT and ASD were measured, along with motor proficiency (Movement ABC-2). We found, on average, the adaptation of saccade gain was reduced for the ADHD-CT group compared to the TD group. Greater saccadic gain change (adaptation) was also positively correlated with higher Movement ABC-2 total and balance scores among the ADHD-CT participants. These differences suggest cerebellar networks underlying saccade adaptation may be disrupted in young people with ADHD-CT. Though our findings require further replication with larger samples, they suggest further research into cerebellar dysfunction in ADHD-CT, and as a point of neurobiological overlap with ASD, may be warranted.
Original language | English |
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Pages (from-to) | 27-34 |
Number of pages | 8 |
Journal | Neuroscience |
Volume | 333 |
DOIs | |
Publication status | Published - 1 Oct 2016 |
Keywords
- adaptation
- Attention Deficit Hyperactivity Disorder
- Autism Spectrum Disorder
- cerebellum
- Motor
- saccade
Projects
- 1 Finished
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Motor functioning in young people with attention deficit hyperactivity disorder - combined type: A three-dimensional motion analysis study
Rinehart, N., Bradshaw, J., Cornish, K., Iansek, R., Tonge, B., McGinley, J. L. & Murphy, A. T.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/11 → 31/12/14
Project: Research