Ruthenium(II) porphyrin catalyzed cyclopropanation of alkenes with tosylhydrazones

Jun Long Zhang, Philip Wai Hong Chan, Chi Ming Che

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Abstract

The diastereoselective ruthenium(II) porphyrin catalyzed cyclopropanation of a variety of alkenes with aryl diazomethanes generated in situ from stable tosylhydrazone derivatives, was achieved in good to excellent yields (up to 92%) and product turnovers. The practical utility of [RuII(p-Cl-TPP)(CO)] (H2(p-Cl-TPP)=meso-tetrakis(p-chlorophenyl)porphyrin) 3 was illustrated in the synthesis of the potent HIV-1 reverse transcriptase inhibitor 10. Preferential formation of sulfone products for reactions involving o- and m-monosubstituted aryl tosylhydrazones demonstrated a hitherto unknown ruthenium(II) porphyrin catalyzed sulfonation reaction.

Original languageEnglish
Pages (from-to)8733-8737
Number of pages5
JournalTetrahedron Letters
Volume44
Issue number48
DOIs
Publication statusPublished - 24 Nov 2003
Externally publishedYes

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