Rotavirus vaccines in developed countries

Jim P. Buttery, Carl Kirkwood

Research output: Contribution to journalReview ArticleResearchpeer-review

24 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Rotavirus is the most common cause of diarrhoea and dehydration in early childhood. The recent licensure in many nations of vaccines against rotavirus offers promise to significantly reduce this toll. The present review describes recent developments regarding rotavirus vaccines and the challenges they face. RECENT FINDINGS: Rotavirus causes significant morbidity and impact upon healthcare systems, at both inpatient and outpatient levels. An earlier rotavirus vaccine, since withdrawn, was temporally associated with intussusception causing small bowel obstruction, especially in infants receiving their first dose at an older age. Large-scale safety and efficacy studies of two new live, oral, attenuated vaccines have shown excellent efficacy against severe rotavirus gastroenteritis. Importantly, both studies detected no association with intussusception with these new vaccines when administered at the scheduled ages. Developed using different rotavirus vaccinology philosophies, questions remain regarding their coverage against new rotavirus serotypes. Ongoing intussusception surveillance following introduction should answer whether they may be safely administered beyond scheduled ages. SUMMARY: Safe, efficacious rotavirus vaccines are available in many developed countries, offering significant promise to reduce the burden of gastroenteritis and dehydration. The impact of these vaccines upon not only morbidity, but also circulating rotavirus serotypes, will be monitored with interest.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalCurrent Opinion in Infectious Diseases
Volume20
Issue number3
DOIs
Publication statusPublished - 1 Jun 2007
Externally publishedYes

Keywords

  • Gastroenteritis
  • Intussusception
  • Rotavirus
  • Vaccines

Cite this

Buttery, Jim P. ; Kirkwood, Carl. / Rotavirus vaccines in developed countries. In: Current Opinion in Infectious Diseases. 2007 ; Vol. 20, No. 3. pp. 253-258.
@article{74d12d9818094fa38764ded274c65393,
title = "Rotavirus vaccines in developed countries",
abstract = "PURPOSE OF REVIEW: Rotavirus is the most common cause of diarrhoea and dehydration in early childhood. The recent licensure in many nations of vaccines against rotavirus offers promise to significantly reduce this toll. The present review describes recent developments regarding rotavirus vaccines and the challenges they face. RECENT FINDINGS: Rotavirus causes significant morbidity and impact upon healthcare systems, at both inpatient and outpatient levels. An earlier rotavirus vaccine, since withdrawn, was temporally associated with intussusception causing small bowel obstruction, especially in infants receiving their first dose at an older age. Large-scale safety and efficacy studies of two new live, oral, attenuated vaccines have shown excellent efficacy against severe rotavirus gastroenteritis. Importantly, both studies detected no association with intussusception with these new vaccines when administered at the scheduled ages. Developed using different rotavirus vaccinology philosophies, questions remain regarding their coverage against new rotavirus serotypes. Ongoing intussusception surveillance following introduction should answer whether they may be safely administered beyond scheduled ages. SUMMARY: Safe, efficacious rotavirus vaccines are available in many developed countries, offering significant promise to reduce the burden of gastroenteritis and dehydration. The impact of these vaccines upon not only morbidity, but also circulating rotavirus serotypes, will be monitored with interest.",
keywords = "Gastroenteritis, Intussusception, Rotavirus, Vaccines",
author = "Buttery, {Jim P.} and Carl Kirkwood",
year = "2007",
month = "6",
day = "1",
doi = "10.1097/QCO.0b013e32813aeaac",
language = "English",
volume = "20",
pages = "253--258",
journal = "Current Opinion in Infectious Diseases",
issn = "0951-7375",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

Rotavirus vaccines in developed countries. / Buttery, Jim P.; Kirkwood, Carl.

In: Current Opinion in Infectious Diseases, Vol. 20, No. 3, 01.06.2007, p. 253-258.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Rotavirus vaccines in developed countries

AU - Buttery, Jim P.

AU - Kirkwood, Carl

PY - 2007/6/1

Y1 - 2007/6/1

N2 - PURPOSE OF REVIEW: Rotavirus is the most common cause of diarrhoea and dehydration in early childhood. The recent licensure in many nations of vaccines against rotavirus offers promise to significantly reduce this toll. The present review describes recent developments regarding rotavirus vaccines and the challenges they face. RECENT FINDINGS: Rotavirus causes significant morbidity and impact upon healthcare systems, at both inpatient and outpatient levels. An earlier rotavirus vaccine, since withdrawn, was temporally associated with intussusception causing small bowel obstruction, especially in infants receiving their first dose at an older age. Large-scale safety and efficacy studies of two new live, oral, attenuated vaccines have shown excellent efficacy against severe rotavirus gastroenteritis. Importantly, both studies detected no association with intussusception with these new vaccines when administered at the scheduled ages. Developed using different rotavirus vaccinology philosophies, questions remain regarding their coverage against new rotavirus serotypes. Ongoing intussusception surveillance following introduction should answer whether they may be safely administered beyond scheduled ages. SUMMARY: Safe, efficacious rotavirus vaccines are available in many developed countries, offering significant promise to reduce the burden of gastroenteritis and dehydration. The impact of these vaccines upon not only morbidity, but also circulating rotavirus serotypes, will be monitored with interest.

AB - PURPOSE OF REVIEW: Rotavirus is the most common cause of diarrhoea and dehydration in early childhood. The recent licensure in many nations of vaccines against rotavirus offers promise to significantly reduce this toll. The present review describes recent developments regarding rotavirus vaccines and the challenges they face. RECENT FINDINGS: Rotavirus causes significant morbidity and impact upon healthcare systems, at both inpatient and outpatient levels. An earlier rotavirus vaccine, since withdrawn, was temporally associated with intussusception causing small bowel obstruction, especially in infants receiving their first dose at an older age. Large-scale safety and efficacy studies of two new live, oral, attenuated vaccines have shown excellent efficacy against severe rotavirus gastroenteritis. Importantly, both studies detected no association with intussusception with these new vaccines when administered at the scheduled ages. Developed using different rotavirus vaccinology philosophies, questions remain regarding their coverage against new rotavirus serotypes. Ongoing intussusception surveillance following introduction should answer whether they may be safely administered beyond scheduled ages. SUMMARY: Safe, efficacious rotavirus vaccines are available in many developed countries, offering significant promise to reduce the burden of gastroenteritis and dehydration. The impact of these vaccines upon not only morbidity, but also circulating rotavirus serotypes, will be monitored with interest.

KW - Gastroenteritis

KW - Intussusception

KW - Rotavirus

KW - Vaccines

UR - http://www.scopus.com/inward/record.url?scp=34247575781&partnerID=8YFLogxK

U2 - 10.1097/QCO.0b013e32813aeaac

DO - 10.1097/QCO.0b013e32813aeaac

M3 - Review Article

C2 - 17471034

AN - SCOPUS:34247575781

VL - 20

SP - 253

EP - 258

JO - Current Opinion in Infectious Diseases

JF - Current Opinion in Infectious Diseases

SN - 0951-7375

IS - 3

ER -