Rotavirus genotypes in malaysia and universal rotavirus vaccination

Way Seah Lee, Benjamin Tze Ying Lim, Pei Fan Chai, Carl D. Kirkwood, Jimmy Kok Foo Lee

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5 Citations (Scopus)

Abstract

Group A rotavirus (RV-A) genotypes isolated in Malaysia was studied to estimate the effectiveness of a universal RV-A vaccination in Malaysia. A simple mathematical model was used, with input from a two-year, two-center, prospective study on hospitalization of RV-A gastroenteritis (RVGE) in young children, published data on RV-A hospitalizations and genotypes, mortality on childhood GE and published genotype-specific efficacy data on two RV-A vaccines. Assuming a 95% vaccine coverage, the overall projected effectiveness was 75.7 to 88.1% for Rotateq® and 78.7 to 90.6% for Rotarix® against RVGE-related hospitalizations. The projected annual reduction in RVGE-related deaths was 27 to 32 deaths (from 34 deaths) for Rotateq® and 28 to 32 deaths annually forRotarix®. A universal RV-A vaccine is efficacious in reducing RVGErelated hospitalizations and mortality in Malaysia.

Original languageEnglish
Pages (from-to)1401-1406
Number of pages6
JournalHuman Vaccines and Immunotherapeutics
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 2012
Externally publishedYes

Keywords

  • Group A rotavirus genotypes
  • Malaysia
  • Universal vaccination

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