Rotavirus

Celeste Donato, Daniel Cowley, Carl Kirkwood

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Diarrheal disease is the second most common cause of death in children under 5 years of age worldwide. Diarrheal disease is also responsible for an estimated 1.5 million deaths/year, accounting for almost 20% of mortality within that age group [1–3]. There are more than 20 different bacterial,viral, and parasitic pathogens that cause diarrheal disease and the proportion and range of pathogens can vary depending on the country [4]. Rotavirus, calicivirus, enteropathogenic, and enterotoxigenic Escherichia coli cause more than half of all diarrheal deaths in children under 5 years of age globally [5]. The Rotavirus genus within the Reoviridae family encompasses a large and diverse group of viruses capable of causing diarrheal disease in infants, children, adults, and the young of a wide variety of animal species [6]. Human group A rotavirus strains were identified in 1973 by Ruth Bishop and colleagues in Australia and rapidly gained recognition as the predominant cause of severe acute gastroenteritis in young children worldwide [7,8]. This chapter will outline the importance of group A rotavirus strains as human pathogens and provide a description of their classification, epidemiology,clinical presentation, diagnosis, treatment, pathogenesis, immunity, transmission, genome,replication, diversity, and vaccines.
Original languageEnglish
Title of host publicationFoodborne Viral Pathogens
EditorsPeter A. White, Natalie E. Netzler, Grant S. Hansman
Place of PublicationAbingdon UK
PublisherTaylor & Francis
Chapter10
Pages179-218
Number of pages40
Edition1st
ISBN (Electronic)9781315392301
ISBN (Print)9781466579507
Publication statusPublished - 2017
Externally publishedYes

Publication series

NameFood Microbiology
PublisherTaylor & Francis Group

Cite this