TY - CHAP
T1 - Rotavirus
AU - Donato, Celeste
AU - Cowley, Daniel
AU - Kirkwood, Carl
PY - 2017
Y1 - 2017
N2 - Diarrheal disease is the second most common cause of death in children under 5 years of age worldwide. Diarrheal disease is also responsible for an estimated 1.5 million deaths/year, accounting for almost 20% of mortality within that age group [1–3]. There are more than 20 different bacterial,viral, and parasitic pathogens that cause diarrheal disease and the proportion and range of pathogens can vary depending on the country [4]. Rotavirus, calicivirus, enteropathogenic, and enterotoxigenic Escherichia coli cause more than half of all diarrheal deaths in children under 5 years of age globally [5]. The Rotavirus genus within the Reoviridae family encompasses a large and diverse group of viruses capable of causing diarrheal disease in infants, children, adults, and the young of a wide variety of animal species [6]. Human group A rotavirus strains were identified in 1973 by Ruth Bishop and colleagues in Australia and rapidly gained recognition as the predominant cause of severe acute gastroenteritis in young children worldwide [7,8]. This chapter will outline the importance of group A rotavirus strains as human pathogens and provide a description of their classification, epidemiology,clinical presentation, diagnosis, treatment, pathogenesis, immunity, transmission, genome,replication, diversity, and vaccines.
AB - Diarrheal disease is the second most common cause of death in children under 5 years of age worldwide. Diarrheal disease is also responsible for an estimated 1.5 million deaths/year, accounting for almost 20% of mortality within that age group [1–3]. There are more than 20 different bacterial,viral, and parasitic pathogens that cause diarrheal disease and the proportion and range of pathogens can vary depending on the country [4]. Rotavirus, calicivirus, enteropathogenic, and enterotoxigenic Escherichia coli cause more than half of all diarrheal deaths in children under 5 years of age globally [5]. The Rotavirus genus within the Reoviridae family encompasses a large and diverse group of viruses capable of causing diarrheal disease in infants, children, adults, and the young of a wide variety of animal species [6]. Human group A rotavirus strains were identified in 1973 by Ruth Bishop and colleagues in Australia and rapidly gained recognition as the predominant cause of severe acute gastroenteritis in young children worldwide [7,8]. This chapter will outline the importance of group A rotavirus strains as human pathogens and provide a description of their classification, epidemiology,clinical presentation, diagnosis, treatment, pathogenesis, immunity, transmission, genome,replication, diversity, and vaccines.
UR - http://www.scopus.com/inward/record.url?scp=85065039075&partnerID=8YFLogxK
M3 - Chapter (Book)
AN - SCOPUS:85065039075
SN - 9781466579507
T3 - Food Microbiology
SP - 179
EP - 218
BT - Foodborne Viral Pathogens
A2 - White, Peter A.
A2 - Netzler, Natalie E.
A2 - Hansman, Grant S.
PB - Taylor & Francis
CY - Abingdon UK
ER -