Rosmarinic acid stimulates liver regeneration through the mTOR pathway

Kaihan Lou, Min Yang, Erdan Duan, Jiahui Zhao, Cong Yu, Rongping Zhang, Lanchun Zhang, Ming Zhang, Zhicheng Xiao, Weiyan Hu, Zhiyong He

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Rosemary (Rosmarinus offcinsalis L) has a liver protection function under various conditions of liver damage. Rosmarinic acid, one of the pharmacological constituents of rosemary, exhibited protective effects against organ injury, including acute liver injury. Hypothesis: We hypothesize that RA stimulates liver regeneration. Study Design: In the present study, we investigated the effects and mechanism of RA administration on liver regeneration using partial hepatectomy (PH), a well-validated liver regeneration model in mice. Methods: We use a 2/3 partial hepatectomy (PH) model to induce liver regeneration. RA was administered prior to and simultaneously with PH. The regeneration process was estimated by the index of the liver to body weight (ILBW) and the expression of proliferating cell nuclear antigen (PCNA) and liver transaminases. Results: The administration of rosmarinic acid stimulated hepatocyte proliferation based on activation of the mTOR/S6K pathway. Rosmarinic acid treatment also rescued impaired liver function due to PH. Conclusion: These data demonstrate that RA is potentially useful to promote liver regeneration.

Original languageEnglish
Pages (from-to)1574-1582
Number of pages9
JournalPhytomedicine : international journal of phytotherapy and phytopharmacology
Volume23
Issue number13
DOIs
Publication statusPublished - 1 Dec 2016

Keywords

  • Liver regeneration
  • mTOR
  • Partial hepatectomy
  • Proliferation
  • Rosemary
  • Rosmarinic acid

Cite this

Lou, Kaihan ; Yang, Min ; Duan, Erdan ; Zhao, Jiahui ; Yu, Cong ; Zhang, Rongping ; Zhang, Lanchun ; Zhang, Ming ; Xiao, Zhicheng ; Hu, Weiyan ; He, Zhiyong. / Rosmarinic acid stimulates liver regeneration through the mTOR pathway. In: Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 ; Vol. 23, No. 13. pp. 1574-1582.
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title = "Rosmarinic acid stimulates liver regeneration through the mTOR pathway",
abstract = "Background: Rosemary (Rosmarinus offcinsalis L) has a liver protection function under various conditions of liver damage. Rosmarinic acid, one of the pharmacological constituents of rosemary, exhibited protective effects against organ injury, including acute liver injury. Hypothesis: We hypothesize that RA stimulates liver regeneration. Study Design: In the present study, we investigated the effects and mechanism of RA administration on liver regeneration using partial hepatectomy (PH), a well-validated liver regeneration model in mice. Methods: We use a 2/3 partial hepatectomy (PH) model to induce liver regeneration. RA was administered prior to and simultaneously with PH. The regeneration process was estimated by the index of the liver to body weight (ILBW) and the expression of proliferating cell nuclear antigen (PCNA) and liver transaminases. Results: The administration of rosmarinic acid stimulated hepatocyte proliferation based on activation of the mTOR/S6K pathway. Rosmarinic acid treatment also rescued impaired liver function due to PH. Conclusion: These data demonstrate that RA is potentially useful to promote liver regeneration.",
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Rosmarinic acid stimulates liver regeneration through the mTOR pathway. / Lou, Kaihan; Yang, Min; Duan, Erdan; Zhao, Jiahui; Yu, Cong; Zhang, Rongping; Zhang, Lanchun; Zhang, Ming; Xiao, Zhicheng; Hu, Weiyan; He, Zhiyong.

In: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 23, No. 13, 01.12.2016, p. 1574-1582.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Lou, Kaihan

AU - Yang, Min

AU - Duan, Erdan

AU - Zhao, Jiahui

AU - Yu, Cong

AU - Zhang, Rongping

AU - Zhang, Lanchun

AU - Zhang, Ming

AU - Xiao, Zhicheng

AU - Hu, Weiyan

AU - He, Zhiyong

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background: Rosemary (Rosmarinus offcinsalis L) has a liver protection function under various conditions of liver damage. Rosmarinic acid, one of the pharmacological constituents of rosemary, exhibited protective effects against organ injury, including acute liver injury. Hypothesis: We hypothesize that RA stimulates liver regeneration. Study Design: In the present study, we investigated the effects and mechanism of RA administration on liver regeneration using partial hepatectomy (PH), a well-validated liver regeneration model in mice. Methods: We use a 2/3 partial hepatectomy (PH) model to induce liver regeneration. RA was administered prior to and simultaneously with PH. The regeneration process was estimated by the index of the liver to body weight (ILBW) and the expression of proliferating cell nuclear antigen (PCNA) and liver transaminases. Results: The administration of rosmarinic acid stimulated hepatocyte proliferation based on activation of the mTOR/S6K pathway. Rosmarinic acid treatment also rescued impaired liver function due to PH. Conclusion: These data demonstrate that RA is potentially useful to promote liver regeneration.

AB - Background: Rosemary (Rosmarinus offcinsalis L) has a liver protection function under various conditions of liver damage. Rosmarinic acid, one of the pharmacological constituents of rosemary, exhibited protective effects against organ injury, including acute liver injury. Hypothesis: We hypothesize that RA stimulates liver regeneration. Study Design: In the present study, we investigated the effects and mechanism of RA administration on liver regeneration using partial hepatectomy (PH), a well-validated liver regeneration model in mice. Methods: We use a 2/3 partial hepatectomy (PH) model to induce liver regeneration. RA was administered prior to and simultaneously with PH. The regeneration process was estimated by the index of the liver to body weight (ILBW) and the expression of proliferating cell nuclear antigen (PCNA) and liver transaminases. Results: The administration of rosmarinic acid stimulated hepatocyte proliferation based on activation of the mTOR/S6K pathway. Rosmarinic acid treatment also rescued impaired liver function due to PH. Conclusion: These data demonstrate that RA is potentially useful to promote liver regeneration.

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