ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer

Dong Gil You, V. G. Deepagan, Wooram Um, Sangmin Jeon, Sejin Son, Hyeyoun Chang, Hwa In Yoon, Yong Woo Cho, Maggie Swierczewska, Seulki Lee, Martin G. Pomper, Ick Chan Kwon, Kwangmeyung Kim, Jae Hyung Park

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236 Citations (Scopus)


The non-invasive photodynamic therapy has been limited to treat superficial tumours, primarily ascribed to poor tissue penetration of light as the energy source. Herein, we designed a long-circulating hydrophilized titanium dioxide nanoparticle (HTiO2 NP) that can be activated by ultrasound to generate reactive oxygen species (ROS). When administered systemically to mice, HTiO2 NPs effectively suppressed the growth of superficial tumours after ultrasound treatments. In tumour tissue, the levels of proinflammatory cytokines were elevated several fold and intense vascular damage was observed. Notably, ultrasound treatments with HTiO2 NPs also suppressed the growth of deeply located liver tumours at least 15-fold, compared to animals without ultrasound treatments. This study provides the first demonstration of the feasibility of using HTiO2 NPs as sensitizers for sonodynamic therapy in vivo.

Original languageEnglish
Article number23200
Number of pages12
JournalScientific Reports
Publication statusPublished - 21 Mar 2016
Externally publishedYes


  • cancer immunotherapy
  • drug delivery
  • nanoparticles
  • targeted therapies

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