RON is not a prognostic marker for resectable pancreatic cancer

Carole M Tactacan; David K Chang; Mark J Cowley; Emily S Humphrey; Jianmin Wu; Anthony J Gill; Angela Chou; Katia Nones; Sean Grimmond; Robert L Sutherland; Andrew V Biankin; Roger John Daly

doi:10.1186/1471-2407-12-395

RON is not a prognostic marker for resectable pancreatic cancer

Carole M Tactacan, David K Chang, Mark J Cowley, Emily S Humphrey, Jianmin Wu, Anthony J Gill, Angela Chou, Katia Nones, Sean Grimmond, Robert L Sutherland, Andrew V Biankin, Roger John Daly

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

BACKGROUND: The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown. METHODS: RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed. RESULTS: RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study. CONCLUSIONS: Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.

Original language	English
Pages (from-to)	1 - 9
Number of pages	9
Journal	BMC Cancer
Volume	12
DOIs	https://doi.org/10.1186/1471-2407-12-395
Publication status	Published - 2012
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1186/1471-2407-12-395

Cite this

@article{bb243c60c46d4bc190b2906665656ba0,

title = "RON is not a prognostic marker for resectable pancreatic cancer",

abstract = "BACKGROUND: The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown. METHODS: RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed. RESULTS: RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study. CONCLUSIONS: Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.",

author = "Tactacan, \{Carole M\} and Chang, \{David K\} and Cowley, \{Mark J\} and Humphrey, \{Emily S\} and Jianmin Wu and Gill, \{Anthony J\} and Angela Chou and Katia Nones and Sean Grimmond and Sutherland, \{Robert L\} and Biankin, \{Andrew V\} and Daly, \{Roger John\}",

year = "2012",

doi = "10.1186/1471-2407-12-395",

language = "English",

volume = "12",

pages = "1 -- 9",

journal = "BMC Cancer",

issn = "1471-2407",

publisher = "BioMed Central",

}

TY - JOUR

T1 - RON is not a prognostic marker for resectable pancreatic cancer

AU - Tactacan, Carole M

AU - Chang, David K

AU - Cowley, Mark J

AU - Humphrey, Emily S

AU - Wu, Jianmin

AU - Gill, Anthony J

AU - Chou, Angela

AU - Nones, Katia

AU - Grimmond, Sean

AU - Sutherland, Robert L

AU - Biankin, Andrew V

AU - Daly, Roger John

PY - 2012

Y1 - 2012

N2 - BACKGROUND: The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown. METHODS: RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed. RESULTS: RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study. CONCLUSIONS: Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.

AB - BACKGROUND: The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown. METHODS: RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed. RESULTS: RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study. CONCLUSIONS: Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.

UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22958871

UR - https://www.scopus.com/pages/publications/84865828068

U2 - 10.1186/1471-2407-12-395

DO - 10.1186/1471-2407-12-395

M3 - Article

SN - 1471-2407

VL - 12

SP - 1

EP - 9

JO - BMC Cancer

JF - BMC Cancer

ER -

RON is not a prognostic marker for resectable pancreatic cancer

Abstract

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