TY - JOUR
T1 - Rolipram promotes remyelination possibly via MEK-ERK signal pathway in cuprizone-induced demyelination mouse
AU - Sun, Xiaojia
AU - Liu, Yuting
AU - Liu, Boyang
AU - Xiao, Zhi-Cheng
AU - Zhang, Liming
PY - 2012
Y1 - 2012
N2 - Rolipram, a 3 ?5 -cyclic adenosine monophosphate (cAMP)-dependent phosphodiesterase 4 (PDE4) inhibitor, has long been studied for its immune modulating effects in the treatment of experimental autoimmune encephalomyelitis (EAE). In the current study, we investigated the effects of rolipram on remyelination after cuprizone- or lysolecithin-induced demyelination and the signal transduction pathways potentially modulating this response.
AB - Rolipram, a 3 ?5 -cyclic adenosine monophosphate (cAMP)-dependent phosphodiesterase 4 (PDE4) inhibitor, has long been studied for its immune modulating effects in the treatment of experimental autoimmune encephalomyelitis (EAE). In the current study, we investigated the effects of rolipram on remyelination after cuprizone- or lysolecithin-induced demyelination and the signal transduction pathways potentially modulating this response.
UR - http://www.sciencedirect.com/science/article/pii/S0014488612002889
U2 - 10.1016/j.expneurol.2012.07.011
DO - 10.1016/j.expneurol.2012.07.011
M3 - Article
SN - 0014-4886
VL - 237
SP - 304
EP - 311
JO - Experimental Neurology
JF - Experimental Neurology
IS - 2
ER -