Rolipram promotes remyelination possibly via MEK-ERK signal pathway in cuprizone-induced demyelination mouse

Xiaojia Sun, Yuting Liu, Boyang Liu, Zhi-Cheng Xiao, Liming Zhang

    Research output: Contribution to journalArticleResearchpeer-review

    29 Citations (Scopus)

    Abstract

    Rolipram, a 3 ?5 -cyclic adenosine monophosphate (cAMP)-dependent phosphodiesterase 4 (PDE4) inhibitor, has long been studied for its immune modulating effects in the treatment of experimental autoimmune encephalomyelitis (EAE). In the current study, we investigated the effects of rolipram on remyelination after cuprizone- or lysolecithin-induced demyelination and the signal transduction pathways potentially modulating this response.
    Original languageEnglish
    Pages (from-to)304 - 311
    Number of pages8
    JournalExperimental Neurology
    Volume237
    Issue number2
    DOIs
    Publication statusPublished - 2012

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