Roles of the NF-kappaB pathway in lymphocyte development and function.

Steve Gerondakis, Ulrich Siebenlist

Research output: Contribution to journalReview ArticleResearchpeer-review

166 Citations (Scopus)

Abstract

This article focuses on the functions of NF-kappaB that vitally impact lymphocytes and thus adaptive immunity. NF-kappaB has long been known to be essential for many of the responses of mature lymphocytes to invading pathogens. In addition, NF-kappaB has important functions in shaping the immune system so it is able to generate adaptive responses to pathogens. In both contexts, NF-kappaB executes critical cell-autonomous functions within lymphocytes as well as within supportive cells, such as antigen-presenting cells or epithelial cells. It is these aspects of NF-kappaB's physiologic impact that we address in this article.

Original languageEnglish
JournalCold Spring Harbor Perspectives in Biology
Volume2
Issue number5
DOIs
Publication statusPublished - 1 May 2010
Externally publishedYes

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