Roles of ligands from the TNF superfamily in B cell development, function, and regulation

William Arthur Figgett, Fabien Vincent, Damien Saulep, Fabienne Mackay-Fisson

Research output: Contribution to journalReview ArticleResearchpeer-review

15 Citations (Scopus)

Abstract

TNF ligands are essential to many aspects of normal B cell biology from development in the bone marrow to maturation in the periphery as well as for activation and differentiation into germinal centre, memory or plasma cells. TNF ligands also influence other aspects of B cell biology such as their ability to present antigens or regulate immune responses. Importantly, inadequate regulation of many TNF ligands is associated with B cell disorders including autoimmunity and cancers. As a result, inhibitors of a number of TNF ligands have been tested in the clinic, with some becoming very successful approved treatments alleviating B cell-mediated pathologies.
Original languageEnglish
Pages (from-to)191 - 202
Number of pages12
JournalSeminars in Immunology
Volume26
Issue number3
DOIs
Publication statusPublished - 2014

Cite this