TY - JOUR
T1 - Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease
AU - Zhang, Fang
AU - Kang, Zhilong
AU - Li, Wen
AU - Xiao, Zhi-Cheng
AU - Zhou, Xinfu
PY - 2012
Y1 - 2012
N2 - Alzheimer s disease (AD) is one of the most common causes of dementia in the elderly. It is characterized by extracellular deposition of the neurotoxic peptide, amyloid-beta (Abeta) peptide fibrils, and is accompanied by extensive loss of neurons in the brains of affected individuals. However, the pathogenesis of AD is not fully understood. The aim of this review is to discuss the possible role of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) signalling in the development of AD, focusing on BDNF/TrkB signalling in the production of Abeta, tau hyperphosphorylation and cognition decline, and exploring new possibilities for AD intervention.
AB - Alzheimer s disease (AD) is one of the most common causes of dementia in the elderly. It is characterized by extracellular deposition of the neurotoxic peptide, amyloid-beta (Abeta) peptide fibrils, and is accompanied by extensive loss of neurons in the brains of affected individuals. However, the pathogenesis of AD is not fully understood. The aim of this review is to discuss the possible role of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) signalling in the development of AD, focusing on BDNF/TrkB signalling in the production of Abeta, tau hyperphosphorylation and cognition decline, and exploring new possibilities for AD intervention.
UR - http://www.sciencedirect.com/science/article/pii/S096758681200135X
U2 - 10.1016/j.jocn.2011.12.022
DO - 10.1016/j.jocn.2011.12.022
M3 - Article
SN - 0967-5868
VL - 19
SP - 946
EP - 949
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
IS - 7
ER -