Projects per year
Abstract
Background and objective: The contribution of non-anatomical factors, such as ventilatory control instability (i.e. LG), to the pathogenesis of obstructive SDB in children is unclear. Therefore, we aimed to identify the relationship between LG and severity of SDB, demographic, anthropometric and anatomical characteristics in a clinically representative cohort of children. Methods: Children (aged 3–18 years) with various severities of SDB (n = 110) and non-snoring controls (n = 36) were studied. Children were grouped according to their OAHI. Anthropometric and upper airway anatomical characteristics were measured. Spontaneous sighs were identified on polysomnography and LG, a measure of the sensitivity of the negative feedback loop that controls ventilation, was estimated by fitting a mathematical model of ventilatory control to the post-sigh ventilatory pattern. Results: There was no difference in LG between controls and any of the SDB severity groups. However, LG was significantly lower in children with larger tonsils (tonsil grade 4) compared with children with smaller tonsils (tonsil grade 1) (median LG (range): 0.25 (0.20–0.42) vs 0.32 (0.25–0.44); P = 0.009) and in children with a modified Mallampati score of class III/IV compared with class I (0.28 (0.24–0.33) vs 0.37 (0.27–0.44); P = 0.009). Conclusion: A direct relationship was not found between the severity of paediatric SDB and LG. However, an altered ventilatory control sensitivity may contribute to SDB in a subgroup of children depending on their degree of anatomical compromise of the airway.
Original language | English |
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Pages (from-to) | 1174-1182 |
Number of pages | 9 |
Journal | Respirology |
Volume | 25 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2020 |
Keywords
- loop gain
- paediatric
- sleep
- sleep-disordered breathing
- ventilatory control
Projects
- 3 Finished
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What role do cerebral hypoxia and sleep disruption play in the neurocognitive effects of paediatric sleep disordered breathing?
Horne, R. (Primary Chief Investigator (PCI)), Biggs, S. (Chief Investigator (CI)), Davey, M. (Chief Investigator (CI)), Nixon, G. (Chief Investigator (CI)) & Walter, L. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/14 → 31/12/17
Project: Research
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Impact of sleep disordered breathing on cardiovascular, behavioural and neurocognitive function in preschool children
Horne, R. (Primary Chief Investigator (PCI)), Catroppa, C. (Chief Investigator (CI)), Davey, M. (Chief Investigator (CI)), Hope, S. (Chief Investigator (CI)), Nixon, G. (Chief Investigator (CI)), O'Driscoll, D. (Chief Investigator (CI)) & Trinder, J. A. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
2/01/08 → 31/12/10
Project: Research
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Cardiovascular, neurophysiological and neurocognitive assessments to define sleep disordered breathing in children ; ID: 384142
Horne, R. (Primary Chief Investigator (PCI)), Anderson, V. (Chief Investigator (CI)), Davey, M. (Chief Investigator (CI)), Trinder, J. A. (Chief Investigator (CI)) & Walker, A. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/06 → 31/12/08
Project: Research