Role of the sympathetic nervous system in schlager genetically hypertensive mice

Pamela J Davern; Thu-Phuc Nguyen-Huu; Luisa La Greca; Amany Abdelkader; Geoffrey A Head

Role of the sympathetic nervous system in schlager genetically hypertensive mice

Pamela J Davern, Thu-Phuc Nguyen-Huu, Luisa La Greca, Amany Abdelkader, Geoffrey A Head

Physiology

Research output: Contribution to journal › Article › Research › peer-review

60 Citations (Scopus)

Abstract

Early studies indicate that the hypertension observed in the Schlager inbred mouse strain may be attributed to a neurogenic mechanism. In this study, we examined the contribution of the sympathetic nervous system in maintaining hypertension in the BPH/2J mouse and used c-Fos immunohistochemistry to elucidate whether neuronal activation in specific brain regions was associated with waking blood pressure. Male hypertensive (BPH/2J; n=14), normotensive (BPN/3J; n=18), and C57/Bl6 (n=5) mice were implanted with telemetry devices, and after 10 days of recovery, recordings of blood pressure, heart rate, and locomotor activity were measured to determine circadian variation. Mean arterial pressure was higher in BPH/2J than in BPN/3J or C57/Bl6 mice (P

Original language	English
Pages (from-to)	852 - 859
Number of pages	8
Journal	Hypertension
Volume	54
Issue number	4
Publication status	Published - 2009

Cite this

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title = "Role of the sympathetic nervous system in schlager genetically hypertensive mice",

abstract = "Early studies indicate that the hypertension observed in the Schlager inbred mouse strain may be attributed to a neurogenic mechanism. In this study, we examined the contribution of the sympathetic nervous system in maintaining hypertension in the BPH/2J mouse and used c-Fos immunohistochemistry to elucidate whether neuronal activation in specific brain regions was associated with waking blood pressure. Male hypertensive (BPH/2J; n=14), normotensive (BPN/3J; n=18), and C57/Bl6 (n=5) mice were implanted with telemetry devices, and after 10 days of recovery, recordings of blood pressure, heart rate, and locomotor activity were measured to determine circadian variation. Mean arterial pressure was higher in BPH/2J than in BPN/3J or C57/Bl6 mice (P",

author = "Davern, {Pamela J} and Thu-Phuc Nguyen-Huu and {La Greca}, Luisa and Amany Abdelkader and Head, {Geoffrey A}",

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AU - Nguyen-Huu, Thu-Phuc

AU - La Greca, Luisa

AU - Abdelkader, Amany

AU - Head, Geoffrey A

PY - 2009

Y1 - 2009

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AB - Early studies indicate that the hypertension observed in the Schlager inbred mouse strain may be attributed to a neurogenic mechanism. In this study, we examined the contribution of the sympathetic nervous system in maintaining hypertension in the BPH/2J mouse and used c-Fos immunohistochemistry to elucidate whether neuronal activation in specific brain regions was associated with waking blood pressure. Male hypertensive (BPH/2J; n=14), normotensive (BPN/3J; n=18), and C57/Bl6 (n=5) mice were implanted with telemetry devices, and after 10 days of recovery, recordings of blood pressure, heart rate, and locomotor activity were measured to determine circadian variation. Mean arterial pressure was higher in BPH/2J than in BPN/3J or C57/Bl6 mice (P

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SP - 852

EP - 859

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 4

ER -

Role of the sympathetic nervous system in schlager genetically hypertensive mice

Abstract

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