Role of the sympathetic nervous system in schlager genetically hypertensive mice

Pamela J Davern, Thu-Phuc Nguyen-Huu, Luisa La Greca, Amany Abdelkader, Geoffrey A Head

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56 Citations (Scopus)

Abstract

Early studies indicate that the hypertension observed in the Schlager inbred mouse strain may be attributed to a neurogenic mechanism. In this study, we examined the contribution of the sympathetic nervous system in maintaining hypertension in the BPH/2J mouse and used c-Fos immunohistochemistry to elucidate whether neuronal activation in specific brain regions was associated with waking blood pressure. Male hypertensive (BPH/2J; n=14), normotensive (BPN/3J; n=18), and C57/Bl6 (n=5) mice were implanted with telemetry devices, and after 10 days of recovery, recordings of blood pressure, heart rate, and locomotor activity were measured to determine circadian variation. Mean arterial pressure was higher in BPH/2J than in BPN/3J or C57/Bl6 mice (P
Original languageEnglish
Pages (from-to)852 - 859
Number of pages8
JournalHypertension
Volume54
Issue number4
Publication statusPublished - 2009

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