Role of RNase H activity in NRTI/NNRTI drug resistance

Gilda Tachedjian; Nicolas Sluis-Cremer

doi:10.1007/978-1-4614-7291-9_13

Role of RNase H activity in NRTI/NNRTI drug resistance

Gilda Tachedjian
, Nicolas Sluis-Cremer

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

1 Citation (Scopus)

Abstract

HIV-1 reverse transcriptase (RT) is responsible for conversion of the viral single-stranded (+)RNA into double-stranded DNA. The enzyme is multifunctional and possesses two distinct activities: (i) a DNA polymerase activity that can use either RNA or DNA as a template and (ii) a ribonuclease H (RNase H) activity that degrades the RNA strand in RNA/DNA duplexes.

Original language	English
Title of host publication	Human Immunodeficiency Virus Reverse Transcriptase: A Bench-to-Bedside Success
Publisher	Springer
Pages	281-303
Number of pages	23
ISBN (Electronic)	9781461472919
ISBN (Print)	1461472903, 9781461472902
DOIs	https://doi.org/10.1007/978-1-4614-7291-9_13
Publication status	Published - 1 Nov 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/978-1-4614-7291-9_13

Cite this

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abstract = "HIV-1 reverse transcriptase (RT) is responsible for conversion of the viral single-stranded (+)RNA into double-stranded DNA. The enzyme is multifunctional and possesses two distinct activities: (i) a DNA polymerase activity that can use either RNA or DNA as a template and (ii) a ribonuclease H (RNase H) activity that degrades the RNA strand in RNA/DNA duplexes.",

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AB - HIV-1 reverse transcriptase (RT) is responsible for conversion of the viral single-stranded (+)RNA into double-stranded DNA. The enzyme is multifunctional and possesses two distinct activities: (i) a DNA polymerase activity that can use either RNA or DNA as a template and (ii) a ribonuclease H (RNase H) activity that degrades the RNA strand in RNA/DNA duplexes.

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BT - Human Immunodeficiency Virus Reverse Transcriptase: A Bench-to-Bedside Success

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ER -

Role of RNase H activity in NRTI/NNRTI drug resistance

Abstract

UN SDGs

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