Role of RNase H activity in NRTI/NNRTI drug resistance

Gilda Tachedjian, Nicolas Sluis-Cremer

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

Abstract

HIV-1 reverse transcriptase (RT) is responsible for conversion of the viral single-stranded (+)RNA into double-stranded DNA. The enzyme is multifunctional and possesses two distinct activities: (i) a DNA polymerase activity that can use either RNA or DNA as a template and (ii) a ribonuclease H (RNase H) activity that degrades the RNA strand in RNA/DNA duplexes.

Original languageEnglish
Title of host publicationHuman Immunodeficiency Virus Reverse Transcriptase: A Bench-to-Bedside Success
PublisherSpringer
Pages281-303
Number of pages23
ISBN (Electronic)9781461472919
ISBN (Print)1461472903, 9781461472902
DOIs
Publication statusPublished - 1 Nov 2013
Externally publishedYes

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