Role of morphogens in neural crest cell determination

Natalie Carmaline Jones, Paul A Trainor

Research output: Contribution to journalArticleOther

30 Citations (Scopus)


The neural crest is a transient, migratory cell population found in all vertebrate embryos that generate a diverse range of cell and tissue derivatives including, but not limited, to the neurons and glia of the peripheral nervous system, smooth muscle, connective tissue, melanocytes, craniofacial cartilage, and bone. Over the past few years, many studies have provided tremendous insights into understanding the mechanisms regulating the induction and migration of neural crest cell development. This review highlights the surprising and perhaps unexpected roles for morphogens in these distinct processes. A comparison of studies performed in several different vertebrates emphasizes the requirement for coordination between multiple signaling pathways in the induction and migration of neural crest cells in the developing embryo
Original languageEnglish
Pages (from-to)388 - 404
Number of pages17
JournalDevelopmental Neurobiology
Issue number4
Publication statusPublished - 2005
Externally publishedYes

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