Role of microRNA machinery in kidney fibrosis

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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that are critical regulators of gene expression at the post-transcriptional level. The miRNAs constitute an abundant class of RNAs conserved from plants to animals, and as such, play key roles in diverse biological processes including inflammation, development, differentiation and apoptosis. More recently it has become apparent that alteration of miRNA expression contributes to a wide spectrum of human pathologies, including heart and kidney disease, organ developmental abnormalities and neuronal degeneration. Moreover, inflammation and the development of kidney fibrosis is accompanied by changes in miRNA expression. This review will summarize the emerging field deciphering the complex connections between human miRNA biology and different aspects of kidney injury, focusing on kidney fibrosis. The miRNA regulated fibrosis will be discussed based on the classification of pivotal mechanisms, notably involving the TGF-beta1 signalling pathway. In addition, the challenge of miRNA delivery vehicles as mechanisms of cellular transfer will be reviewed, and the use of miRNA as potential biomarkers for disease This article is protected by copyright. All rights reserved.
Original languageEnglish
Pages (from-to)543 - 550
Number of pages8
JournalClinical and Experimental Pharmacology and Physiology
Volume41
Issue number8
DOIs
Publication statusPublished - 2014

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