Role of metal ions in the cognitive decline of Down syndrome

Nakisa Malakooti, Melanie A Pritchard, Paul A Adlard, David Isaac Finkelstein

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17 Citations (Scopus)


Down syndrome (DS), caused by trisomy of whole or part of chromosome 21 is the most common mental impairment. All people with DS suffer from cognitive decline and develop Alzheimer s disease (AD) by the age of 40. The appearance of enlarged early endosomes, followed by Amyloid betapeptide deposition, the appearance of tau-containing neurofibrillary tangles and basal forebrain cholinergic neuron (BFCN) degeneration are the neuropathological characteristics of this disease. In this review we will examine the role of metal ion dyshomeostasis and the genes which may be involved in these processes, and relate these back to the manifestation of age-dependent cognitive decline in DS.
Original languageEnglish
Pages (from-to)1 - 6
Number of pages6
JournalFrontiers in Aging Neuroscience
Issue numberArt. No.:136
Publication statusPublished - 2014

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