TY - JOUR
T1 - Role of metal ions in the cognitive decline of Down syndrome
AU - Malakooti, Nakisa
AU - Pritchard, Melanie A
AU - Adlard, Paul A
AU - Finkelstein, David Isaac
PY - 2014
Y1 - 2014
N2 - Down syndrome (DS), caused by trisomy of whole or part of chromosome 21 is the most common mental impairment. All people with DS suffer from cognitive decline and develop Alzheimer s disease (AD) by the age of 40. The appearance of enlarged early endosomes, followed by Amyloid betapeptide deposition, the appearance of tau-containing neurofibrillary tangles and basal forebrain cholinergic neuron (BFCN) degeneration are the neuropathological characteristics of this disease. In this review we will examine the role of metal ion dyshomeostasis and the genes which may be involved in these processes, and relate these back to the manifestation of age-dependent cognitive decline in DS.
AB - Down syndrome (DS), caused by trisomy of whole or part of chromosome 21 is the most common mental impairment. All people with DS suffer from cognitive decline and develop Alzheimer s disease (AD) by the age of 40. The appearance of enlarged early endosomes, followed by Amyloid betapeptide deposition, the appearance of tau-containing neurofibrillary tangles and basal forebrain cholinergic neuron (BFCN) degeneration are the neuropathological characteristics of this disease. In this review we will examine the role of metal ion dyshomeostasis and the genes which may be involved in these processes, and relate these back to the manifestation of age-dependent cognitive decline in DS.
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066992/pdf/fnagi-06-00136.pdf
U2 - 10.3389/fnagi.2014.00136
DO - 10.3389/fnagi.2014.00136
M3 - Article
SN - 1663-4365
VL - 6
SP - 1
EP - 6
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
IS - Art. No.:136
ER -