Role of macrophages in the immunopathogenesis of HIV-1 infection

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Macrophages have important functions in both alerting and activating the immune system. They have the ability to activate both the innate and adaptive immune responses through their role as antigen presenting cells, presenting viral antigens to immune cells. They can further reduce the viral burden by removing dead and dying cells, and they themselves contain several restriction factors that offer a level of protection against HIV-1 infection. However, macrophages also have a central role in the pathogenesis of HIV-1 infection. Through the secretion of chemokines, they can recruit T cells to the site of infection and provide new cellular targets for HIV-1. They have the ability to harbor HIV-1 in their internal vesicles, and facilitate infection of cells through cell,–cell transfer of HIV-1. In addition, macrophages have a long-life span, and through persistent infection and recruitment of cellular targets, they can contribute to the viral reservoir. A viral reservoir is a cell or anatomical site where replication-competent HIV-1 accumulates and persists stably. Additionally macrophages, reside in multiple tissues within the body, including the central nervous system, creating complications for immune detection and penetration of current antiretroviral therapies. The multi faceted role of macrophages during HIV-1 disease pathogenesis makes them important immune cells to be considered in future HIV-1 elimination strategies.

Original languageEnglish
Title of host publicationGlobal Virology I-Identifying and Investigating Viral Diseases
EditorsPaul Shapshak, John T. Sinnott, Charurut Somboonwit, Jens H. Kuhn
Place of PublicationNew York NY USA
PublisherSpringer
Pages723-744
Number of pages22
ISBN (Electronic)978-1-4939-2410-3
ISBN (Print)978-1-4939-2409-7
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Chemokines
  • Cytokines
  • HIV-1
  • Immune activation
  • Immunopathogenesis
  • Macrophages

Cite this

Flynn, J. K., & Gorry, P. R. (2015). Role of macrophages in the immunopathogenesis of HIV-1 infection. In P. Shapshak, J. T. Sinnott, C. Somboonwit, & J. H. Kuhn (Eds.), Global Virology I-Identifying and Investigating Viral Diseases (pp. 723-744). New York NY USA: Springer. https://doi.org/10.1007/978-1-4939-2410-3_27
Flynn, Jacqueline K. ; Gorry, Paul R. / Role of macrophages in the immunopathogenesis of HIV-1 infection. Global Virology I-Identifying and Investigating Viral Diseases. editor / Paul Shapshak ; John T. Sinnott ; Charurut Somboonwit ; Jens H. Kuhn. New York NY USA : Springer, 2015. pp. 723-744
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Flynn, JK & Gorry, PR 2015, Role of macrophages in the immunopathogenesis of HIV-1 infection. in P Shapshak, JT Sinnott, C Somboonwit & JH Kuhn (eds), Global Virology I-Identifying and Investigating Viral Diseases. Springer, New York NY USA, pp. 723-744. https://doi.org/10.1007/978-1-4939-2410-3_27

Role of macrophages in the immunopathogenesis of HIV-1 infection. / Flynn, Jacqueline K.; Gorry, Paul R.

Global Virology I-Identifying and Investigating Viral Diseases. ed. / Paul Shapshak; John T. Sinnott; Charurut Somboonwit; Jens H. Kuhn. New York NY USA : Springer, 2015. p. 723-744.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

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Flynn JK, Gorry PR. Role of macrophages in the immunopathogenesis of HIV-1 infection. In Shapshak P, Sinnott JT, Somboonwit C, Kuhn JH, editors, Global Virology I-Identifying and Investigating Viral Diseases. New York NY USA: Springer. 2015. p. 723-744 https://doi.org/10.1007/978-1-4939-2410-3_27