During foetal development in humans, primitive haemopoietic stem cells appear in the dorsal aorta, then migrate to the liver and finally reside in the bone marrow. The stroma of these haemopoietic organs forms a specific microenvironment in which a network of cytokines is produced to control the development, renewal and homeostasis of the haemopoietic system. Haemopoietic stem cells are in intimate contact with the stroma through specific adhesive interactions between cell adhesion molecules produced by the stroma and adhesion receptors expressed by haemopoietic precursors. The aim of this review is to present and discuss the function of adhesion receptors belonging to the integrin and sialomucin superfamilies whose essential role in migration, development and homeostasis of haemopoietic stem cells has been recently demonstrated in vivo.
|Number of pages||11|
|Publication status||Published - 2001|
- Bone marrow
- Cell adhesion
- Hemopoietic stem cell