Abstract
| Original language | English |
|---|---|
| Article number | 37678 |
| Number of pages | 11 |
| Journal | Scientific Reports |
| Volume | 6 |
| DOIs | |
| Publication status | Published - 24 Nov 2016 |
Keywords
- embryology
- lipid signalling
Cite this
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Role of ectonucleotide pyrophosphatase/phosphodiesterase 2 in the midline axis formation of zebrafish. / Frisca, Frisca; Colquhoun, Daniel; Goldshmit, Yona; Anko, Minna-Liisa; Pebay, Alice; Kaslin, Jan.
In: Scientific Reports, Vol. 6, 37678, 24.11.2016.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Role of ectonucleotide pyrophosphatase/phosphodiesterase 2 in the midline axis formation of zebrafish
AU - Frisca, Frisca
AU - Colquhoun, Daniel
AU - Goldshmit, Yona
AU - Anko, Minna-Liisa
AU - Pebay, Alice
AU - Kaslin, Jan
PY - 2016/11/24
Y1 - 2016/11/24
N2 - Lysophosphatidic acid (LPA) is a unique bioactive lysophospholipid that induces pleiotropic effects in various cell types and organisms by acting on its specific receptors. LPA is mainly synthetised extracellularly by the ectonucleotide pyrophosphatase/phosphodiesterase 2/autotaxin (enpp2). Altered LPA signalling is associated with embryonic abnormalities, suggesting critical roles for LPA during development. However, the role of LPA signalling during early embryogenesis is not well established. We demonstrate that enpp2/LPA signalling in the early zebrafish embryo results in altered axis and midline formation, defects in left right (L-R) patterning, ciliogenesis of the Kupffer’s vesicle (KV), through the modulation of cell migration during gastrulation in a lpar1–3Rho/ROCK-dependant manner. Overall, this study demonstrates an essential role of enpp2/LPA signalling during early embryogenesis.
AB - Lysophosphatidic acid (LPA) is a unique bioactive lysophospholipid that induces pleiotropic effects in various cell types and organisms by acting on its specific receptors. LPA is mainly synthetised extracellularly by the ectonucleotide pyrophosphatase/phosphodiesterase 2/autotaxin (enpp2). Altered LPA signalling is associated with embryonic abnormalities, suggesting critical roles for LPA during development. However, the role of LPA signalling during early embryogenesis is not well established. We demonstrate that enpp2/LPA signalling in the early zebrafish embryo results in altered axis and midline formation, defects in left right (L-R) patterning, ciliogenesis of the Kupffer’s vesicle (KV), through the modulation of cell migration during gastrulation in a lpar1–3Rho/ROCK-dependant manner. Overall, this study demonstrates an essential role of enpp2/LPA signalling during early embryogenesis.
KW - embryology
KW - lipid signalling
UR - http://www.scopus.com/inward/record.url?scp=84997288018&partnerID=8YFLogxK
U2 - 10.1038/srep37678
DO - 10.1038/srep37678
M3 - Article
VL - 6
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 37678
ER -