Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids

Natalie Debeljuh, Swapna Varghese, Colin J Barrow, Nolene Byrne

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6 Citations (Scopus)

Abstract

We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the A 16-22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.

Original languageEnglish
Pages (from-to)1502-1506
Number of pages5
JournalAustralian Journal of Chemistry
Volume65
Issue number11
DOIs
Publication statusPublished - 2012
Externally publishedYes

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