Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids

Natalie Debeljuh; Swapna Varghese; Colin J Barrow; Nolene Byrne

doi:10.1071/CH12316

Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids

Natalie Debeljuh, Swapna Varghese, Colin J Barrow, Nolene Byrne

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the A 16-22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.

Original language	English
Pages (from-to)	1502-1506
Number of pages	5
Journal	Australian Journal of Chemistry
Volume	65
Issue number	11
DOIs	https://doi.org/10.1071/CH12316
Publication status	Published - 2012
Externally published	Yes

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10.1071/CH12316

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AB - We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the A 16-22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.

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Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids

Abstract

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