Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids

Natalie Debeljuh, Swapna Varghese, Colin J Barrow, Nolene Byrne

Research output: Contribution to journalArticleResearchpeer-review

Abstract

We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the A 16-22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.

Original languageEnglish
Pages (from-to)1502-1506
Number of pages5
JournalAustralian Journal of Chemistry
Volume65
Issue number11
DOIs
Publication statusPublished - 2012
Externally publishedYes

Cite this

@article{0f35823e56ec4896823ed876e3bc1818,
title = "Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids",
abstract = "We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the A 16-22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.",
author = "Natalie Debeljuh and Swapna Varghese and Barrow, {Colin J} and Nolene Byrne",
year = "2012",
doi = "10.1071/CH12316",
language = "English",
volume = "65",
pages = "1502--1506",
journal = "Australian Journal of Chemistry",
issn = "0004-9425",
publisher = "CSIRO Publishing",
number = "11",

}

Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids. / Debeljuh, Natalie; Varghese, Swapna; Barrow, Colin J; Byrne, Nolene.

In: Australian Journal of Chemistry, Vol. 65, No. 11, 2012, p. 1502-1506.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids

AU - Debeljuh, Natalie

AU - Varghese, Swapna

AU - Barrow, Colin J

AU - Byrne, Nolene

PY - 2012

Y1 - 2012

N2 - We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the A 16-22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.

AB - We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the A 16-22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.

UR - http://www.scopus.com/inward/record.url?scp=84869849484&partnerID=8YFLogxK

U2 - 10.1071/CH12316

DO - 10.1071/CH12316

M3 - Article

VL - 65

SP - 1502

EP - 1506

JO - Australian Journal of Chemistry

JF - Australian Journal of Chemistry

SN - 0004-9425

IS - 11

ER -