Role of c-KIT expression level and phosphatidylinositol 3-kinase activation in survival and proliferative responses of early myeloid cells

Sonia McCallum, Anthony Cambareri, Leonie Ashman

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

The receptor tyrosine kinase c-KIT and its ligand Stem Cell Factor are critical in haemopoiesis but pathways linking receptor activation to specific responses in progenitor cells are still unclear. We have investigated the role of c-KIT expression level and the phosphatidylinositol 3-kinase pathway in survival and cell division of early myeloid cells in response to SCF.
Original languageEnglish
Pages (from-to)608 - 620
Number of pages13
JournalCellular Signalling
Volume18
DOIs
Publication statusPublished - 2006

Cite this