Role of c-KIT expression level and phosphatidylinositol 3-kinase activation in survival and proliferative responses of early myeloid cells

Sonia McCallum; Anthony Cambareri; Leonie Ashman

doi:10.1016/j.cellsig.2005.06.005

Role of c-KIT expression level and phosphatidylinositol 3-kinase activation in survival and proliferative responses of early myeloid cells

Sonia McCallum, Anthony Cambareri, Leonie Ashman

Health Systems Services & Policy

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Abstract

The receptor tyrosine kinase c-KIT and its ligand Stem Cell Factor are critical in haemopoiesis but pathways linking receptor activation to specific responses in progenitor cells are still unclear. We have investigated the role of c-KIT expression level and the phosphatidylinositol 3-kinase pathway in survival and cell division of early myeloid cells in response to SCF.

Original language	English
Pages (from-to)	608 - 620
Number of pages	13
Journal	Cellular Signalling
Volume	18
DOIs	https://doi.org/10.1016/j.cellsig.2005.06.005
Publication status	Published - 2006

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10.1016/j.cellsig.2005.06.005

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@article{e0aa62a15389493ea44b9c55d89331b3,

title = "Role of c-KIT expression level and phosphatidylinositol 3-kinase activation in survival and proliferative responses of early myeloid cells",

abstract = "The receptor tyrosine kinase c-KIT and its ligand Stem Cell Factor are critical in haemopoiesis but pathways linking receptor activation to specific responses in progenitor cells are still unclear. We have investigated the role of c-KIT expression level and the phosphatidylinositol 3-kinase pathway in survival and cell division of early myeloid cells in response to SCF.",

author = "Sonia McCallum and Anthony Cambareri and Leonie Ashman",

year = "2006",

doi = "10.1016/j.cellsig.2005.06.005",

language = "English",

volume = "18",

pages = "608 -- 620",

journal = "Cellular Signalling",

issn = "0898-6568",

publisher = "Elsevier",

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TY - JOUR

T1 - Role of c-KIT expression level and phosphatidylinositol 3-kinase activation in survival and proliferative responses of early myeloid cells

AU - McCallum, Sonia

AU - Cambareri, Anthony

AU - Ashman, Leonie

PY - 2006

Y1 - 2006

N2 - The receptor tyrosine kinase c-KIT and its ligand Stem Cell Factor are critical in haemopoiesis but pathways linking receptor activation to specific responses in progenitor cells are still unclear. We have investigated the role of c-KIT expression level and the phosphatidylinositol 3-kinase pathway in survival and cell division of early myeloid cells in response to SCF.

AB - The receptor tyrosine kinase c-KIT and its ligand Stem Cell Factor are critical in haemopoiesis but pathways linking receptor activation to specific responses in progenitor cells are still unclear. We have investigated the role of c-KIT expression level and the phosphatidylinositol 3-kinase pathway in survival and cell division of early myeloid cells in response to SCF.

UR - http://www.sciencedirect.com/science/article/pii/S0898656805001403

U2 - 10.1016/j.cellsig.2005.06.005

DO - 10.1016/j.cellsig.2005.06.005

M3 - Article

VL - 18

SP - 608

EP - 620

JO - Cellular Signalling

JF - Cellular Signalling

SN - 0898-6568

ER -

Role of c-KIT expression level and phosphatidylinositol 3-kinase activation in survival and proliferative responses of early myeloid cells

Abstract

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