Role of brain angiotensin II in renal nerve inhibition elicited by volume expansion in the conscious rabbit

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Losartan (10 μg/25 μl) or vehicle was injected into the fourth brain ventricle prior to volume expansion (VE) with Haemaccel (2 ml/min for 30 min). RSNA was reduced by a maximum of 45% in response to the VE following vehicle and by 33% following losartan. There was no significant difference between the treatments in RSNA, nor in the blood pressure and heart rate responses. We conclude that endogenous angiotensin II does not make a major contribution to the reflex reduction in RSNA initiated by VE. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalBrain Research
Issue number2
Publication statusPublished - 21 Jul 2000


  • Endogenous angiotensin II
  • Losartan
  • Volume expansion

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