Role of beta-Adrenoceptors in Memory Consolidation: beta3-Adrenoceptors Act on Glucose Uptake and beta2-Adrenoceptors on Glycogenolysis

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Abstract

Noradrenaline, acting via 2- and 3-adrenoceptors (AR), enhances memory formation in single trial-discriminated avoidance learning in day-old chicks by mechanisms involving changes in metabolism of glucose and/or glycogen. Earlier studies of memory consolidation in chicks implicated 3- rather than 2-ARs in enhancement of memory consolidation by glucose, but did not elucidate whether stimulation of glucose uptake or of glycolysis was responsible. This study examines the role of glucose transport in memory formation using central injection of the nonselective facilitative glucose transporter (GLUT) inhibitor cytochalasin B, the endothelial/astrocytic GLUT-1 inhibitor phloretin and the Na+/energy-dependent endothelial glucose transporter (SGLT) inhibitor phlorizin. Cytochalasin B inhibited memory when injected into the mesopallium (avian cortex) either close to or between 25 and 45 min after training, whereas phloretin and phlorizin only inhibited memory at 30 min. This suggested that astrocytic/endothelial (GLUT-1) transport is critical at the time of consolidation, whereas a different transporter, probably the neuronal glucose transporter (GLUT-3), is important at the time of training. Inhibition of glucose transport by cytochalasin B, phloretin, or phlorizin also interfered with 3-AR-mediated memory enhancement 20 min posttraining, whereas inhibition of glycogenolysis interfered with 2-AR agonist enhancement of memory. We conclude that in astrocytes (1) activities of both GLUT-1 and SGLT are essential for memory consolidation 30 min posttraining; (2) neuronal GLUT-3 is essential at the time of training; and (3) 2- and 3-ARs consolidate memory by different mechanisms; 3-ARs stimulate central glucose transport, whereas 2-ARs stimulate central glycogenolysis.
Original languageEnglish
Pages (from-to)2384 - 2397
Number of pages13
JournalNeuropsychopharmacology
Volume33
Publication statusPublished - 2008

Cite this

@article{e22b773291104758b64968e0b7506050,
title = "Role of beta-Adrenoceptors in Memory Consolidation: beta3-Adrenoceptors Act on Glucose Uptake and beta2-Adrenoceptors on Glycogenolysis",
abstract = "Noradrenaline, acting via 2- and 3-adrenoceptors (AR), enhances memory formation in single trial-discriminated avoidance learning in day-old chicks by mechanisms involving changes in metabolism of glucose and/or glycogen. Earlier studies of memory consolidation in chicks implicated 3- rather than 2-ARs in enhancement of memory consolidation by glucose, but did not elucidate whether stimulation of glucose uptake or of glycolysis was responsible. This study examines the role of glucose transport in memory formation using central injection of the nonselective facilitative glucose transporter (GLUT) inhibitor cytochalasin B, the endothelial/astrocytic GLUT-1 inhibitor phloretin and the Na+/energy-dependent endothelial glucose transporter (SGLT) inhibitor phlorizin. Cytochalasin B inhibited memory when injected into the mesopallium (avian cortex) either close to or between 25 and 45 min after training, whereas phloretin and phlorizin only inhibited memory at 30 min. This suggested that astrocytic/endothelial (GLUT-1) transport is critical at the time of consolidation, whereas a different transporter, probably the neuronal glucose transporter (GLUT-3), is important at the time of training. Inhibition of glucose transport by cytochalasin B, phloretin, or phlorizin also interfered with 3-AR-mediated memory enhancement 20 min posttraining, whereas inhibition of glycogenolysis interfered with 2-AR agonist enhancement of memory. We conclude that in astrocytes (1) activities of both GLUT-1 and SGLT are essential for memory consolidation 30 min posttraining; (2) neuronal GLUT-3 is essential at the time of training; and (3) 2- and 3-ARs consolidate memory by different mechanisms; 3-ARs stimulate central glucose transport, whereas 2-ARs stimulate central glycogenolysis.",
author = "Gibbs, {Marie Elizabeth} and Hutchinson, {Dana Sabine} and Summers, {Roger James}",
year = "2008",
language = "English",
volume = "33",
pages = "2384 -- 2397",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",

}

Role of beta-Adrenoceptors in Memory Consolidation: beta3-Adrenoceptors Act on Glucose Uptake and beta2-Adrenoceptors on Glycogenolysis. / Gibbs, Marie Elizabeth; Hutchinson, Dana Sabine; Summers, Roger James.

In: Neuropsychopharmacology, Vol. 33, 2008, p. 2384 - 2397.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Role of beta-Adrenoceptors in Memory Consolidation: beta3-Adrenoceptors Act on Glucose Uptake and beta2-Adrenoceptors on Glycogenolysis

AU - Gibbs, Marie Elizabeth

AU - Hutchinson, Dana Sabine

AU - Summers, Roger James

PY - 2008

Y1 - 2008

N2 - Noradrenaline, acting via 2- and 3-adrenoceptors (AR), enhances memory formation in single trial-discriminated avoidance learning in day-old chicks by mechanisms involving changes in metabolism of glucose and/or glycogen. Earlier studies of memory consolidation in chicks implicated 3- rather than 2-ARs in enhancement of memory consolidation by glucose, but did not elucidate whether stimulation of glucose uptake or of glycolysis was responsible. This study examines the role of glucose transport in memory formation using central injection of the nonselective facilitative glucose transporter (GLUT) inhibitor cytochalasin B, the endothelial/astrocytic GLUT-1 inhibitor phloretin and the Na+/energy-dependent endothelial glucose transporter (SGLT) inhibitor phlorizin. Cytochalasin B inhibited memory when injected into the mesopallium (avian cortex) either close to or between 25 and 45 min after training, whereas phloretin and phlorizin only inhibited memory at 30 min. This suggested that astrocytic/endothelial (GLUT-1) transport is critical at the time of consolidation, whereas a different transporter, probably the neuronal glucose transporter (GLUT-3), is important at the time of training. Inhibition of glucose transport by cytochalasin B, phloretin, or phlorizin also interfered with 3-AR-mediated memory enhancement 20 min posttraining, whereas inhibition of glycogenolysis interfered with 2-AR agonist enhancement of memory. We conclude that in astrocytes (1) activities of both GLUT-1 and SGLT are essential for memory consolidation 30 min posttraining; (2) neuronal GLUT-3 is essential at the time of training; and (3) 2- and 3-ARs consolidate memory by different mechanisms; 3-ARs stimulate central glucose transport, whereas 2-ARs stimulate central glycogenolysis.

AB - Noradrenaline, acting via 2- and 3-adrenoceptors (AR), enhances memory formation in single trial-discriminated avoidance learning in day-old chicks by mechanisms involving changes in metabolism of glucose and/or glycogen. Earlier studies of memory consolidation in chicks implicated 3- rather than 2-ARs in enhancement of memory consolidation by glucose, but did not elucidate whether stimulation of glucose uptake or of glycolysis was responsible. This study examines the role of glucose transport in memory formation using central injection of the nonselective facilitative glucose transporter (GLUT) inhibitor cytochalasin B, the endothelial/astrocytic GLUT-1 inhibitor phloretin and the Na+/energy-dependent endothelial glucose transporter (SGLT) inhibitor phlorizin. Cytochalasin B inhibited memory when injected into the mesopallium (avian cortex) either close to or between 25 and 45 min after training, whereas phloretin and phlorizin only inhibited memory at 30 min. This suggested that astrocytic/endothelial (GLUT-1) transport is critical at the time of consolidation, whereas a different transporter, probably the neuronal glucose transporter (GLUT-3), is important at the time of training. Inhibition of glucose transport by cytochalasin B, phloretin, or phlorizin also interfered with 3-AR-mediated memory enhancement 20 min posttraining, whereas inhibition of glycogenolysis interfered with 2-AR agonist enhancement of memory. We conclude that in astrocytes (1) activities of both GLUT-1 and SGLT are essential for memory consolidation 30 min posttraining; (2) neuronal GLUT-3 is essential at the time of training; and (3) 2- and 3-ARs consolidate memory by different mechanisms; 3-ARs stimulate central glucose transport, whereas 2-ARs stimulate central glycogenolysis.

UR - http://www.nature.com/npp/journal/v33/n10/full/1301629a.html

M3 - Article

VL - 33

SP - 2384

EP - 2397

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

ER -