Role of agglomeration in the dispersion of salmeterol xinafoate from mixtures for inhalation with differing drug to fine lactose ratios

Handoko Adi, Ian Clair Larson, Herbert Chiou, Paul Michael Young, Daniela Traini, Peter James Stewart

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28 Citations (Scopus)

Abstract

The purpose of this study was to characterise the role of agglomeration on slameterol xinafoate (SX) dispersion from mixtures for inhalation by varying the SX concentration and the proportion of fine lactose (FL). SX concentrations and SX:FL ratios ranged from 1.0 to 5.0 (w/w) and from 1:0 to 1:8, respectively. The in vitro deposition of SX was measured using a twin stage impinger (TSI). The aerosol was characterised by particulate capture in the TSI stages and subsequent imaging by scanning electron microscopy and by real-time particle sizing. The presence of coarse lactose reduced SX concentration. SX dispersion in binary mixtures of SX and FL was independent of SX:FL ratio and was similar to that of carrier-based mixtures with high particulate loads. Increased concentrations of SX and proportions of FL in carrier-based mixtures resulted in increased SX dispersion. Agglomerate formation coincided with increased dispersion. The study demonstrated that agglomeration is one of the important factors in SX dispersion from carrier-based mixtures at high particulate loads.
Original languageEnglish
Pages (from-to)3140 - 3152
Number of pages12
JournalJournal of Pharmaceutical Sciences
Volume97
Issue number1
DOIs
Publication statusPublished - 2008

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