Role of ADARs in Mouse development

Carl R. Walkley, Brian Liddicoat, Jochen C. Hartner

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

8 Citations (Scopus)

Abstract

RNA editing by deamination of adenosine to inosine (A-to-I editing) is a physiologically important posttranscriptional mechanism that can regulate expression of genes by modifying their transcripts. A-to-I editing is mediated by adenosine deaminases acting on RNA (ADAR) that can catalytically exchange adenosines to inosines, with varying efficiency, depending on the structure of the RNA substrates. Significant progress in understanding the biological function of mammalian ADARs has been made in the past decade by the creation and analysis of gene-targeted mice with disrupted or modified ADAR alleles. These studies have revealed important roles of ADARs in neuronal and hematopoietic tissue during embryonic and postnatal stages of mouse development.

Original languageEnglish
Title of host publicationAdenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing
PublisherSpringer
Pages197-220
Number of pages24
Edition1st
ISBN (Electronic)9783642228018
ISBN (Print)9783642228001
DOIs
Publication statusPublished - 2012
Externally publishedYes

Publication series

NameCurrent Topics in Microbiology and Immunology
Number1
Volume353
ISSN (Print)0070-217X

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