@article{b04fa03c7a8a4ddda5fa65831774563b,
title = "Role of activin A in the pathogenesis of endothelial cell dysfunction in preeclampsia",
abstract = "Circulating markers for endothelial activation such as endothelin-1 (ET-1), ICAM-1 and VCAM-1 are elevated in women with preeclampsia. Using human umbilical vein endothelial cells (HUVECs) as an in vitro model of the maternal vasculature, we show that activin A and preeclamptic serum upregulate ET-1, ICAM-1, and VCAM-1 in HUVECs. Further, we show that follistatin, a specific binding protein for activin, mitigates the upregulation of ET-1, ICAM-1 and VCAM-1 in HUVECs exposed to either activin A or preeclamptic serum. These data are consistent with activin A contributing to the pathophysiology of preeclampsia and suggest that therapies targeting activin signalling are worth exploring.",
keywords = "Preeclampsia, Activin, Follistatin, Endothelin, ICAM, VCAM",
author = "Hobson, {Sebastian R.} and Rutu Acharya and Rebecca Lim and Chan, {Siow Teng} and Joanne Mockler and Wallace, {Euan M.}",
year = "2016",
month = apr,
doi = "10.1016/j.preghy.2016.03.001",
language = "English",
volume = "6",
pages = "130--133",
journal = "Pregnancy Hypertension",
issn = "2210-7789",
publisher = "Elsevier BV",
number = "2",
}