Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis

Stuart W. Haynes, Paulina K. Sydor, Anna E. Stanley, Lijiang Song, Gregory L. Challis

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Abstract

The function of RedH from Streptomyces coelicolor as an enzyme that catalyses the condensation of 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde (MBC) and 2-undecylpyrrole to form the natural product undecylprodiginine has been experimentally proven, and the substrate specificity of RedH has been probed in vivo by examining its ability to condense chemically-synthesised MBC analogues with 2-undecylpyrrole to afford undecylprodiginine analogues.

Original languageEnglish
Pages (from-to)1865-1867
Number of pages3
JournalChemical Communications
Issue number16
DOIs
Publication statusPublished - 14 Apr 2008
Externally publishedYes

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