RNA virus reassortment: An evolutionary mechanism for host jumps and immune evasion

Dhanasekaran Vijaykrishna; Reshmi Mukerji; Gavin J. D. Smith

doi:10.1371/journal.ppat.1004902

RNA virus reassortment: An evolutionary mechanism for host jumps and immune evasion

Dhanasekaran Vijaykrishna, Reshmi Mukerji, Gavin J. D. Smith

Research output: Contribution to journal › Article › Other › peer-review

98 Citations (Scopus)

Abstract

Reassortment is an evolutionary mechanism of segmented RNA viruses that plays an important but ill-defined role in virus emergence and interspecies transmission. Recent experimental studies have greatly enhanced our understanding of the cellular mechanisms of reassortment within a host cell. Our purpose here is to offer a brief introduction on the role of reassortment in segmented RNA virus evolution, explain the host cellular mechanisms of reassortment, and provide a synthesis of recent experimental findings and methodological developments. While we focus our discussion on influenza viruses, wherein most of the studies on reassortment have been carried out, the concepts presented are broadly applicable to other multipartite genomes.

Original language	English
Article number	e1004902
Number of pages	6
Journal	PLoS Pathogens
Volume	11
Issue number	7
DOIs	https://doi.org/10.1371/journal.ppat.1004902
Publication status	Published - 9 Jul 2015
Externally published	Yes

Keywords

influenza viruses
viral genomics
RNA viruses
evolutionary emergence
host cells
influenza
animal phylogenetics
viral evolution

Access to Document

10.1371/journal.ppat.1004902

16548978-oaFinal published version, 303 KB

Cite this

@article{c021bdb25bce4ba6aff24bd1e2cce1cb,

title = "RNA virus reassortment: An evolutionary mechanism for host jumps and immune evasion",

abstract = "Reassortment is an evolutionary mechanism of segmented RNA viruses that plays an important but ill-defined role in virus emergence and interspecies transmission. Recent experimental studies have greatly enhanced our understanding of the cellular mechanisms of reassortment within a host cell. Our purpose here is to offer a brief introduction on the role of reassortment in segmented RNA virus evolution, explain the host cellular mechanisms of reassortment, and provide a synthesis of recent experimental findings and methodological developments. While we focus our discussion on influenza viruses, wherein most of the studies on reassortment have been carried out, the concepts presented are broadly applicable to other multipartite genomes.",

keywords = "influenza viruses, viral genomics, RNA viruses, evolutionary emergence, host cells, influenza, animal phylogenetics, viral evolution",

author = "Dhanasekaran Vijaykrishna and Reshmi Mukerji and Smith, {Gavin J. D.}",

year = "2015",

month = jul,

day = "9",

doi = "10.1371/journal.ppat.1004902",

language = "English",

volume = "11",

journal = "PLoS Pathogens",

issn = "1553-7366",

publisher = "Public Library of Science (PLoS)",

number = "7",

}

TY - JOUR

T1 - RNA virus reassortment

T2 - An evolutionary mechanism for host jumps and immune evasion

AU - Vijaykrishna, Dhanasekaran

AU - Mukerji, Reshmi

AU - Smith, Gavin J. D.

PY - 2015/7/9

Y1 - 2015/7/9

N2 - Reassortment is an evolutionary mechanism of segmented RNA viruses that plays an important but ill-defined role in virus emergence and interspecies transmission. Recent experimental studies have greatly enhanced our understanding of the cellular mechanisms of reassortment within a host cell. Our purpose here is to offer a brief introduction on the role of reassortment in segmented RNA virus evolution, explain the host cellular mechanisms of reassortment, and provide a synthesis of recent experimental findings and methodological developments. While we focus our discussion on influenza viruses, wherein most of the studies on reassortment have been carried out, the concepts presented are broadly applicable to other multipartite genomes.

AB - Reassortment is an evolutionary mechanism of segmented RNA viruses that plays an important but ill-defined role in virus emergence and interspecies transmission. Recent experimental studies have greatly enhanced our understanding of the cellular mechanisms of reassortment within a host cell. Our purpose here is to offer a brief introduction on the role of reassortment in segmented RNA virus evolution, explain the host cellular mechanisms of reassortment, and provide a synthesis of recent experimental findings and methodological developments. While we focus our discussion on influenza viruses, wherein most of the studies on reassortment have been carried out, the concepts presented are broadly applicable to other multipartite genomes.

KW - influenza viruses

KW - viral genomics

KW - RNA viruses

KW - evolutionary emergence

KW - host cells

KW - influenza

KW - animal phylogenetics

KW - viral evolution

UR - http://www.scopus.com/inward/record.url?scp=84938791943&partnerID=8YFLogxK

UR - http://journals.plos.org/plospathogens/article/asset?id=10.1371/journal.ppat.1004902.PDF

U2 - 10.1371/journal.ppat.1004902

DO - 10.1371/journal.ppat.1004902

M3 - Article

AN - SCOPUS:84938791943

SN - 1553-7366

VL - 11

JO - PLoS Pathogens

JF - PLoS Pathogens

IS - 7

M1 - e1004902

ER -

RNA virus reassortment: An evolutionary mechanism for host jumps and immune evasion

Abstract

Keywords

Access to Document

Other files and links

Cite this