TY - JOUR
T1 - Risk profiling of aflatoxin in peanut (Arachis hypogaea L.) to the Filipino consuming population
AU - Rustia, Abigail S.
AU - Mariano, Christine Bernadette D.G.
AU - Bautista, Karina Angela D.
AU - Mahoney, Deon
AU - Barrios, Erniel B.
AU - Villarino, Casiana Blanca J.
AU - Limon, Mark R.
AU - Capanzana, Mario V.
N1 - Funding Information:
The process of risk profiling is also described as “qualitative risk assessment” (WHO 2020). The resulting risk profile sought to serve as reference material for risk managers in evaluating risks to the Filipino consuming population and to aid in the decision-making and proposition of possible mitigation measures. This study was conducted from 2019–2020 under the DOST– Philippine Council for Industry, Energy and Emerging Technology Research and Development (PCIEERD) Project No. 05340, known as the Philippine Food Safety Risk Profiling Project (PRPP).
Publisher Copyright:
© 2022, Department of Science and Technology. All rights reserved.
PY - 2022/10
Y1 - 2022/10
N2 - Aflatoxin (AFL) is a naturally occurring mycotoxin produced by Aspergillus spp. and is commonly associated with peanuts (Arachis hypogaea L.), a major field legume in the Philippines. The major types of AFL are B1, B2, G1, and G2 – comprising the total aflatoxin (AFT). AFL exposure has been shown to cause both chronic and acute toxicity, with the liver as the main target organ. It is considered genotoxic and carcinogenic. The objective of this study is to establish the profile of the potential risks associated with the consumption of peanuts contaminated with aflatoxin to the Filipino consuming population. The study included [1] determination of data gaps in the risk profiling of AFL in the consumption of peanuts by the Filipino peanut-consuming population; [2] hazard identification and characterization; [3] estimation of dietary exposure (DE) and risk-based on uncertainties, variabilities, and assumptions; and [4] consolidation of available control measures and possible mitigation protocols for AFL in peanut. AFL was detected in 92% of all the peanut samples (n = 50) analyzed, with overall mean levels of 802.83 µg/kg AFT, 683.53 µg/kg AFB1, and 119.30 µg/kg AFB2 exceeding the maximum level (ML) of 15 µg/kg set by the Codex Alimentarius Commission for AFT. Considering the assumptions made and data gathered in this study, the estimated daily intakes (EDIs) of the Filipino adult (20–59 yr old) consuming population to AFT and to AFB1 in peanut – at 97.5th percentile consumption – were 1.22–6,527.18 ng/kg body weight (bw)/d and 1.22–5,574.90 ng/kg bw/d, respectively, which exceeded the recommended provisional maximum tolerable daily intake (PMTDI) of 1 ng/kg bw/d. The margins of exposure (MOE) were also generally estimated to be below 10,000, which indicates that it is a potential health concern and that it supports the need for further risk management actions.
AB - Aflatoxin (AFL) is a naturally occurring mycotoxin produced by Aspergillus spp. and is commonly associated with peanuts (Arachis hypogaea L.), a major field legume in the Philippines. The major types of AFL are B1, B2, G1, and G2 – comprising the total aflatoxin (AFT). AFL exposure has been shown to cause both chronic and acute toxicity, with the liver as the main target organ. It is considered genotoxic and carcinogenic. The objective of this study is to establish the profile of the potential risks associated with the consumption of peanuts contaminated with aflatoxin to the Filipino consuming population. The study included [1] determination of data gaps in the risk profiling of AFL in the consumption of peanuts by the Filipino peanut-consuming population; [2] hazard identification and characterization; [3] estimation of dietary exposure (DE) and risk-based on uncertainties, variabilities, and assumptions; and [4] consolidation of available control measures and possible mitigation protocols for AFL in peanut. AFL was detected in 92% of all the peanut samples (n = 50) analyzed, with overall mean levels of 802.83 µg/kg AFT, 683.53 µg/kg AFB1, and 119.30 µg/kg AFB2 exceeding the maximum level (ML) of 15 µg/kg set by the Codex Alimentarius Commission for AFT. Considering the assumptions made and data gathered in this study, the estimated daily intakes (EDIs) of the Filipino adult (20–59 yr old) consuming population to AFT and to AFB1 in peanut – at 97.5th percentile consumption – were 1.22–6,527.18 ng/kg body weight (bw)/d and 1.22–5,574.90 ng/kg bw/d, respectively, which exceeded the recommended provisional maximum tolerable daily intake (PMTDI) of 1 ng/kg bw/d. The margins of exposure (MOE) were also generally estimated to be below 10,000, which indicates that it is a potential health concern and that it supports the need for further risk management actions.
KW - aflatoxin
KW - peanut
KW - Philippines
KW - risk
KW - risk profile
UR - http://www.scopus.com/inward/record.url?scp=85139869618&partnerID=8YFLogxK
U2 - 10.56899/151.05.02
DO - 10.56899/151.05.02
M3 - Article
AN - SCOPUS:85139869618
SN - 0031-7683
VL - 151
SP - 1557
EP - 1577
JO - Philippine Journal of Science
JF - Philippine Journal of Science
IS - 5
ER -