TY - JOUR
T1 - Risk of motor vehicle collisions and culpability among older drivers using cannabis
T2 - a meta-analysis
AU - Chinna-Meyyappan, Arun
AU - Wang, Hui Jue
AU - Bawa, Kritleen K.
AU - Ellazar, Edward
AU - Norris-Roozmon, Emilie
AU - Naglie, Gary
AU - Herrmann, Nathan
AU - Charlton, Judith L.
AU - Koppel, Sjaan
AU - Castel, Saulo
AU - Lanctôt, Krista L.
AU - Rapoport, Mark J.
N1 - Funding Information:
This paper was supported by funding from the Alzheimer’s Drug Discovery Foundation (Grant No: 2,016,354), Weston Brain Institute (WBI) (CT190002), Canadian Consortium on Neurodegeneration in Aging, which is supported by a grant from the Canadian Institutes of Health Research with funding from several partners, Toronto Cannabis and Cannabinoid Research Consortium (TC3) Fellowship, Glaxo Wellcome-Sunnybrook Drug Safety Clinic Graduate Student Fellowship.
Funding Information:
K L. Lanctôt reports grants from Alzheimer’s Association (PTC-18-543,823, PTCG-20-700,751), Alzheimer Society of Canada, Alzheimer’s Drug Discovery Foundation (Grant No: 2,016,354), Canadian Institutes Health Research (FRNs PJ2 179,753, PJT183584), National Institute on Aging (R01AG046543), and Weston Brain Institute (CT190002); consulting fees from BioXcel Therapeutics, Bright Minds, Cerevel Therapeutics, Eisai Co. Ltd., Exciva, ICG Pharma, Jazz Pharmaceuticals, Kondor Pharma, H Lundbeck A/S, Merck, Novo Nordisk, Praxis Therapeutics, Sumitomo Pharma Co. Ltd.; stock options from Highmark Interactive outside the submitted work. Dr. Rapoport acknowledges research funding from Sunnybrook Psychiatrists, Canadian Institute for Health Research, Canadian Consortium on Neurodegeneration and Aging, Alzheimer’s Association, and Alzheimer’s Society of Canada. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Publisher Copyright:
© 2023 by the authors.
PY - 2023
Y1 - 2023
N2 - Limited studies have investigated the effects of cannabis use on driving among older adults, who represent the fastest growing segment of drivers globally. We conducted a systematic review and meta-analysis to evaluate the effects of delta-9-tetrahydrocannabinol (THC) exposure on risks of (1) motor vehicle collisions (MVC) and (2) culpability for MVCs among adults 50 years and older. Three reviewers screened 7022 studies identified through MEDLINE, EMBASE, CENTRAL, and PsycINFO. Odds Ratios (OR) were calculated using the Mantel-Haenszel method in Review Manager 5.4.1. Heterogeneity was assessed using I2. The National Heart, Lung, and Blood Institute tool was used to assess the quality of each study. Seven cross-sectional studies were included. Three studies evaluated culpability while four evaluated MVC. The pooled risk of MVC was not significantly different between THC-positive and THC-negative older drivers (OR, 95% CI 1.15 [0.40, 3.31]; I2 = 72%). In culpability studies, THC exposure was not significantly associated with an increased risk of being culpable for MVC among adults over the age of 50 (OR, 95% CI 1.24 [0.95, 1.61]; I2 = 0%). Inspection of funnel plots did not indicate publication bias. Our review found that THC exposure was not associated with MVC involvement nor with culpability for MVCs.
AB - Limited studies have investigated the effects of cannabis use on driving among older adults, who represent the fastest growing segment of drivers globally. We conducted a systematic review and meta-analysis to evaluate the effects of delta-9-tetrahydrocannabinol (THC) exposure on risks of (1) motor vehicle collisions (MVC) and (2) culpability for MVCs among adults 50 years and older. Three reviewers screened 7022 studies identified through MEDLINE, EMBASE, CENTRAL, and PsycINFO. Odds Ratios (OR) were calculated using the Mantel-Haenszel method in Review Manager 5.4.1. Heterogeneity was assessed using I2. The National Heart, Lung, and Blood Institute tool was used to assess the quality of each study. Seven cross-sectional studies were included. Three studies evaluated culpability while four evaluated MVC. The pooled risk of MVC was not significantly different between THC-positive and THC-negative older drivers (OR, 95% CI 1.15 [0.40, 3.31]; I2 = 72%). In culpability studies, THC exposure was not significantly associated with an increased risk of being culpable for MVC among adults over the age of 50 (OR, 95% CI 1.24 [0.95, 1.61]; I2 = 0%). Inspection of funnel plots did not indicate publication bias. Our review found that THC exposure was not associated with MVC involvement nor with culpability for MVCs.
KW - cannabis
KW - culpability
KW - delta-9-tetrahydrocannabinol
KW - driving
KW - motor vehicle collision
KW - older adults
KW - road traffic crashes
KW - THC
UR - https://www.scopus.com/pages/publications/85151420794
U2 - 10.3390/brainsci13030421
DO - 10.3390/brainsci13030421
M3 - Review Article
C2 - 36979231
AN - SCOPUS:85151420794
SN - 2076-3425
VL - 13
JO - Brain Sciences
JF - Brain Sciences
IS - 3
M1 - 421
ER -