TY - JOUR
T1 - Risk of death among persons with Alzheimer's disease: A national register-based nested case-control study
AU - Lonnroos, Eija
AU - Kyyronen, Pentti
AU - Bell, John Simon Frederick
AU - van der Cammen, Tischa JM
AU - Hartikainen, Sirpa
PY - 2013
Y1 - 2013
N2 - Few studies have reported the risk of death related to Alzheimer s disease (AD) in large population-based cohorts. The objective of this study was to analyze the impact of AD on all-cause mortality in a nationwide sample of persons with AD. Community-dwelling persons with AD and an equal number of individually matched (age, gender, and region of residence) control persons without AD were identified from the registers of Social Insurance Institution of Finland at the end of 2005. Deaths in this sample (n = 56,041, mean age 79.7 years, 67.8 women) during a 57-month follow-up period were recorded. Using a nested case-control design, unadjusted and adjusted (cardiovascular disease, cancer, diabetes, and asthma and/or COPD) hazard ratios (HR) with 95 confidence intervals (CI) were computed using proportional hazards regression. The results were categorized according to age at death (
AB - Few studies have reported the risk of death related to Alzheimer s disease (AD) in large population-based cohorts. The objective of this study was to analyze the impact of AD on all-cause mortality in a nationwide sample of persons with AD. Community-dwelling persons with AD and an equal number of individually matched (age, gender, and region of residence) control persons without AD were identified from the registers of Social Insurance Institution of Finland at the end of 2005. Deaths in this sample (n = 56,041, mean age 79.7 years, 67.8 women) during a 57-month follow-up period were recorded. Using a nested case-control design, unadjusted and adjusted (cardiovascular disease, cancer, diabetes, and asthma and/or COPD) hazard ratios (HR) with 95 confidence intervals (CI) were computed using proportional hazards regression. The results were categorized according to age at death (
UR - http://iospress.metapress.com/content/1424918161u2v5l7/fulltext.pdf
U2 - 10.3233/JAD-2012-120808
DO - 10.3233/JAD-2012-120808
M3 - Article
SN - 1387-2877
VL - 33
SP - 157
EP - 164
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -
