Risk of death among persons with Alzheimer's disease: A national register-based nested case-control study

Eija Lonnroos, Pentti Kyyronen, John Simon Frederick Bell, Tischa JM van der Cammen, Sirpa Hartikainen

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30 Citations (Scopus)


Few studies have reported the risk of death related to Alzheimer s disease (AD) in large population-based cohorts. The objective of this study was to analyze the impact of AD on all-cause mortality in a nationwide sample of persons with AD. Community-dwelling persons with AD and an equal number of individually matched (age, gender, and region of residence) control persons without AD were identified from the registers of Social Insurance Institution of Finland at the end of 2005. Deaths in this sample (n = 56,041, mean age 79.7 years, 67.8 women) during a 57-month follow-up period were recorded. Using a nested case-control design, unadjusted and adjusted (cardiovascular disease, cancer, diabetes, and asthma and/or COPD) hazard ratios (HR) with 95 confidence intervals (CI) were computed using proportional hazards regression. The results were categorized according to age at death (
Original languageEnglish
Pages (from-to)157 - 164
Number of pages8
JournalJournal of Alzheimer's Disease
Issue number1
Publication statusPublished - 2013
Externally publishedYes

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