Risk Factors for Intraprocedural and Clinically Significant Delayed Bleeding After Wide-field Endoscopic Mucosal Resection of Large Colonic Lesions

Nicholas G. Burgess, Andrew J. Metz, Stephen J. Williams, Rajvinder Singh, William Tam, Luke F. Hourigan, Simon A. Zanati, Gregor J. Brown, Rebecca Sonson, Michael J. Bourke

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Abstract

Background & Aims: Wide-field endoscopic mucosal resection (WF-EMR) of large sessile colonic polyps is a safe and cost-effective outpatient treatment. Bleeding is the main complication. Few studies have examined risk factors for bleeding during the procedure (intraprocedural bleeding [IPB]) or after it (clinically significant post-endoscopic bleeding [CSPEB]). We investigated factors associated with IPB and CSPEB in a large prospective study. Methods: We analyzed data from WF-EMRs of sessile colorectal polyps ≥20 mm in size (mean size, 35.5mm), which were performed on 1172 patients (mean age, 67.8 years) from June 2008-March 2013 at 7 tertiary hospitals as part of the Australian Colonic Endoscopic Resection Study. Data were collected on characteristics of patients and lesions, along with outcomes of procedures and clinical and histologic analyses. Independent predictors of IPB and CSPEB were identified by multiple logistic regression analysis. Results: Of the patients studied, 133 (11.3%) had IPB. Independent predictors included increasing lesion size (odds ratio, 1.24/10 mm; P < .001), Paris endoscopic classification of 0-IIa+ Is (odds ratio, 2.12; P= .004), tubulovillous or villous histology (odds ratio, 1.84; P= .007), and study institutions that performed the procedure on fewer than 75 patients (odds ratio, 3.78; P<.001). All IPB was successfully controlled endoscopically. IPB prolonged procedures and was associated with early recurrence (relative risk, 1.68; P= .011). Seventy-three patients (6.2%) had CSPEB. On multivariable analysis, CSPEB was associated with proximal colon location (odds ratio, 3.72; P < .001), use of an electrosurgical current not controlled by a microprocessor (odds ratio, 2.03; P= .038), and IPB (odds ratio, 2.16; P= .016). Lesion size and comorbidities did not predict CSPEB. Conclusions: In a prospective study of patients undergoing WF-EMR of large sessile colonic polyps, IPB is associated with larger lesions, lesion histology, and Paris endoscopic classification of type 0-IIa+ Is. IPB prolongs the duration of the procedure, is a marker for recurrence, and is associated with CSPEB. CSPEB occurs most frequently in the proximal colon and less when current is controlled by a microprocessor.

Original languageEnglish
Pages (from-to)651-661.e3
Number of pages14
JournalClinical Gastroenterology and Hepatology
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 2014
Externally publishedYes

Keywords

  • ACE study
  • Colonoscopy
  • Colorectal neoplasms
  • Hemorrhage
  • Polypectomy

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