Risk factors for eosinophilic esophagitis

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Eosinophilic esophagitis (EoE) is a chronic antigen driven disease, whereby food and/or aeroallergens result in inflammation and luminal narrowing, and the clinical symptoms of dysphagia and food bolus obstruction events (FBOE). Established risk factors are male gender, Caucasian race and atopy. Increased risk amongst family members, and a single nucleotide polymorphism (SNP) in a gene coding thymic stromal lymphopoietin (TSLP) on the pseudoautosomal region of the X and Y chromosomes supports a genetic predisposition. Environmental factors including the timing and nature of food and aeroallergen exposure to the developing immune system may be important, whilst esophageal barrier function integrity and the influence of microbiota are worthy of future research.
Original languageEnglish
Pages (from-to)1012 - 1019
Number of pages8
JournalClinical and Experimental Allergy
Volume44
Issue number8
DOIs
Publication statusPublished - 2014

Cite this

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title = "Risk factors for eosinophilic esophagitis",
abstract = "Eosinophilic esophagitis (EoE) is a chronic antigen driven disease, whereby food and/or aeroallergens result in inflammation and luminal narrowing, and the clinical symptoms of dysphagia and food bolus obstruction events (FBOE). Established risk factors are male gender, Caucasian race and atopy. Increased risk amongst family members, and a single nucleotide polymorphism (SNP) in a gene coding thymic stromal lymphopoietin (TSLP) on the pseudoautosomal region of the X and Y chromosomes supports a genetic predisposition. Environmental factors including the timing and nature of food and aeroallergen exposure to the developing immune system may be important, whilst esophageal barrier function integrity and the influence of microbiota are worthy of future research.",
author = "Hamish Philpott and Sanjay Nandurkar and Royce, {Simon G} and Francis Thien and Gibson, {Peter R}",
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Risk factors for eosinophilic esophagitis. / Philpott, Hamish; Nandurkar, Sanjay; Royce, Simon G; Thien, Francis; Gibson, Peter R.

In: Clinical and Experimental Allergy, Vol. 44, No. 8, 2014, p. 1012 - 1019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Risk factors for eosinophilic esophagitis

AU - Philpott, Hamish

AU - Nandurkar, Sanjay

AU - Royce, Simon G

AU - Thien, Francis

AU - Gibson, Peter R

PY - 2014

Y1 - 2014

N2 - Eosinophilic esophagitis (EoE) is a chronic antigen driven disease, whereby food and/or aeroallergens result in inflammation and luminal narrowing, and the clinical symptoms of dysphagia and food bolus obstruction events (FBOE). Established risk factors are male gender, Caucasian race and atopy. Increased risk amongst family members, and a single nucleotide polymorphism (SNP) in a gene coding thymic stromal lymphopoietin (TSLP) on the pseudoautosomal region of the X and Y chromosomes supports a genetic predisposition. Environmental factors including the timing and nature of food and aeroallergen exposure to the developing immune system may be important, whilst esophageal barrier function integrity and the influence of microbiota are worthy of future research.

AB - Eosinophilic esophagitis (EoE) is a chronic antigen driven disease, whereby food and/or aeroallergens result in inflammation and luminal narrowing, and the clinical symptoms of dysphagia and food bolus obstruction events (FBOE). Established risk factors are male gender, Caucasian race and atopy. Increased risk amongst family members, and a single nucleotide polymorphism (SNP) in a gene coding thymic stromal lymphopoietin (TSLP) on the pseudoautosomal region of the X and Y chromosomes supports a genetic predisposition. Environmental factors including the timing and nature of food and aeroallergen exposure to the developing immune system may be important, whilst esophageal barrier function integrity and the influence of microbiota are worthy of future research.

UR - http://onlinelibrary.wiley.com/doi/10.1111/cea.12363/pdf

U2 - 10.1111/cea.12363

DO - 10.1111/cea.12363

M3 - Article

VL - 44

SP - 1012

EP - 1019

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

SN - 0954-7894

IS - 8

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