Risk factors for eosinophilic esophagitis

Hamish Philpott, Sanjay Nandurkar, Simon G Royce, Francis Thien, Peter R Gibson

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


Eosinophilic esophagitis (EoE) is a chronic antigen driven disease, whereby food and/or aeroallergens result in inflammation and luminal narrowing, and the clinical symptoms of dysphagia and food bolus obstruction events (FBOE). Established risk factors are male gender, Caucasian race and atopy. Increased risk amongst family members, and a single nucleotide polymorphism (SNP) in a gene coding thymic stromal lymphopoietin (TSLP) on the pseudoautosomal region of the X and Y chromosomes supports a genetic predisposition. Environmental factors including the timing and nature of food and aeroallergen exposure to the developing immune system may be important, whilst esophageal barrier function integrity and the influence of microbiota are worthy of future research.
Original languageEnglish
Pages (from-to)1012 - 1019
Number of pages8
JournalClinical and Experimental Allergy
Issue number8
Publication statusPublished - 2014

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