Risk and response adapted therapy for early stage Hodgkin lymphoma: A prospective multicenter study of the Australasian Leukaemia and lymphoma group/trans-tasman radiation oncology group

Andrew Wirth, Andrew Grigg, Max Wolf, David Goldstein, Carol Johnson, Sidney Davis, Gaelle Dutu, Poppy Kypreos, Carole Smith, Andrew Kneebone, Mark Herzberg, David Joseph, John Catalano, Daniel Roos, Janey Stone, John Reynolds

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In this prospective, multicenter, non-randomized study for patients with stage I-II Hodgkin lymphoma, group 1 (without risk-factors [RF]) had three cycles of ABVD chemotherapy (adriamycin, bleomycin, vinblastine, and dacarbazine) and group 2 (any of bulk, extranodal site, >3 regions, raised erythrocyte sedimentation rate [ESR]) and group 3 (B-symptoms) received four cycles. Involved field radiotherapy (IFRT) 30 Gy was given after adequate chemotherapy response. Five-year overall survival and freedom from progression (FFP) were 96% (95% confidence interval [CI] 91-98%) and 90% (84-94%), respectively. Five-year FFP was 97% (90-99%), 89% (75-95%), and 73% (52-86%) for groups 1, 2, and 3, respectively. In patients with RF, chemotherapy responses of complete response unconfirmed (CRu), partial response (PR), and stable disease (SD) were associated with FFP of 90%, 86%, and 62% (p=0.17), and CR/no CR on functional imaging with FFP of 90%/67%, respectively (p=0.05). The 97% FFP in group 1 compares favorably with previously reported results from cooperative trial groups. Intensification of therapy warrants study in patients with RF and a poor chemotherapy response.

Original languageEnglish
Pages (from-to)786-795
Number of pages10
JournalLeukemia and Lymphoma
Issue number5
Publication statusPublished - May 2011
Externally publishedYes


  • chemotherapeutic approaches
  • Lymphoma and Hodgkin disease
  • prognostication
  • radiation

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